Optical clearing of the eye sclera in vivo caused by glucose

Journal Article · Sun Dec 31 00:00:00 EST 2006 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QE2006V036N12ABEH013337· OSTI ID:21456918

Genina, Elina A; Bashkatov, A N; Sinichkin, Yu P; Tuchin, Valerii V ^[1]

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1. Department of Optics and Biomedical Physics, N.G.Chernyshevskii Saratov State University (Russian Federation)

Changes in the optical properties of the eye sclera of a laboratory animal (rabbit) caused by the noninvasive administration of an immersion agent (aqueous glucose solution) into sclera are studied experimentally in vivo by the method of reflection spectroscopy and simulated numerically. The diffusion coefficients of glucose and water in sclera are estimated from simulations of optical clearing within the framework of the developed model as h(5.4{+-}0.1)x10{sup -7} and (5.8{+-}0.2)x10{sup -7} cm{sup 2} s{sup -1}, respectively. Experiments showed that the application of the glucose solution on the sclera allows the efficient control of its optical properties, which makes it possible to deliver the laser energy to internal eye tissues without considerable attenuation and distortions of its spatial distribution in laser diagnostics and therapy. (special issue devoted to multiple radiation scattering in random media)

• OSTI ID: 21456918
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Vol. 36, Issue 12; Other Information: DOI: 10.1070/QE2006v036n12ABEH013337; ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
AQUEOUS SOLUTIONS
DIAGNOSTIC TECHNIQUES
DIFFUSION
EYES
GLUCOSE
IN VIVO
LABORATORY ANIMALS
LASERS
OPTICAL PROPERTIES
RABBITS
REFLECTION
SIMULATION
SPATIAL DISTRIBUTION
SPECTROSCOPY
THERAPY
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
DISPERSIONS
DISTRIBUTION
FACE
HEAD
HEXOSES
HOMOGENEOUS MIXTURES
MAMMALS
MEDICINE
MIXTURES
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PHYSICAL PROPERTIES
SACCHARIDES
SENSE ORGANS
SOLUTIONS
VERTEBRATES