Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes

Journal Article · Sat Nov 30 00:00:00 EST 2002 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QE2002V032N11ABEH002334· OSTI ID:21450534

Kuranov, R V; Sapozhnikova, V V; Shakhova, N M; Gelikonov, V M; Zagainova, E V; Petrova, S A ^[1]

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1. Institute of Applied Physics, Russian Academy of Sciences, Nizhnii Novgorod (Russian Federation)

A combined application of optical methods [optical coherent tomography (OCT), cross-polarisation optical coherent tomography, and fluorescence spectroscopy] is proposed for obtaining information on morphological and biochemical changes occurring in tissues in norm and pathology. It is shown that neoplastic and scar changes in esophagus can be distinguished using a combination of polarisation and standard OCT due to the difference between the depolarising properties of the tissues caused by the structural properties of collagenic fibres in stroma. It is shown that OCT combined with fluorescence spectroscopy with the use of 5-aminolevulinic acid is promising for determining the boundaries of carcinoma of the uterine cervix and vulva. It is found that the tumour boundary detected by optical methods coincides with the morphological boundary and extends beyond colposcopically determined boundary by about 2 mm. (laser biology and medicine)

• OSTI ID: 21450534
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Vol. 32, Issue 11; Other Information: DOI: 10.1070/QE2002v032n11ABEH002334; ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
AMINOLEVULINIC ACID
CARCINOMAS
ESOPHAGUS
FLUORESCENCE SPECTROSCOPY
OPTICAL SYSTEMS
PATHOLOGY
POLARIZATION
TOMOGRAPHY
AMINO ACIDS
BODY
CARBOXYLIC ACIDS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
EMISSION SPECTROSCOPY
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
SPECTROSCOPY