Combination of fluorescence imaging and local spectrophotometry in fluorescence diagnostics of early cancer of larynx and bronchi

Journal Article · Sat Nov 30 00:00:00 EST 2002 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QE2002V032N11ABEH002329· OSTI ID:21450532

Sokolov, Vladimir V; Filonenko, E V; Telegina, L V ^[1]; Boulgakova, N N; Smirnov, V V ^[2]

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1. P.A. Hertsen Moscow Research Oncological Institute, Moscow (Russian Federation)
2. A.M. Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation)

The results of comparative studies of autofluorescence and 5-ALA-induced fluorescence of protoporphyrin IX, used in the diagnostics of early cancer of larynx and bronchi, are presented. The autofluorescence and 5-ALA-induced fluorescence images of larynx and bronchial tissues are analysed during the endoscopic study. The method of local spectrophotometry is used to verify findings obtained from fluorescence images. It is shown that such a combined approach can be efficiently used to improve the diagnostics of precancer and early cancer, to detect a primary multiple tumours, as well as for the diagnostics of a residual tumour or an early recurrence after the endoscopic, surgery or X-ray treatment. The developed approach allows one to minimise the number of false-positive results and to reduce the number of biopsies, which are commonly used in the white-light bronchoscopy search for occult cancerous loci. (laser biology and medicine)

• OSTI ID: 21450532
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Vol. 32, Issue 11; Other Information: DOI: 10.1070/QE2002v032n11ABEH002329; ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
BIOPSY
BRONCHI
FLUORESCENCE
IMAGES
LARYNX
NEOPLASMS
PROTOPORPHYRINS
SPECTROPHOTOMETRY
SURGERY
VISIBLE RADIATION
X RADIATION
CARBOXYLIC ACIDS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTROMAGNETIC RADIATION
EMISSION
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
LUMINESCENCE
MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHOTON EMISSION
PIGMENTS
PORPHYRINS
RADIATIONS
RESPIRATORY SYSTEM