Catheter-Directed Thrombolysis of Inferior Vena Cava Thrombosis in a 13-Day-Old Neonate and Review of Literature

Journal Article · Tue Jul 15 00:00:00 EDT 2008 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-007-9229-9· OSTI ID:21450386

Khan, Jawad U ^[1]; Takemoto, Clifford M; Casella, James F ^[2]; Streiff, Michael B ^[3]; Nwankwo, Ikechi J

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1. Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science (United States)
2. Johns Hopkins University School of Medicine, Department of Pediatrics (United States)
3. Johns Hopkins University School of Medicine, Department of Medicine (United States)

Complete inferior vena cava thrombosis (IVC) in neonates is uncommon, but may cause significant morbidity. A 13-day-old neonate suffered IVC thrombosis secondary to antithrombin III deficiency, possibly contributed to by a mutation in the methyl tetrahydrofolate reductase gene. Catheter-directed thrombolysis (CDT) with recombinant tissue plasminogen activator (rt-PA, Alteplase) was used successfully to treat extensive venous thrombosis in this neonate without complications. We also review the literature on CDT for treatment of IVC thrombosis in critically ill neonates and infants.

• OSTI ID: 21450386
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 31, Issue 2; Other Information: DOI: 10.1007/s00270-007-9229-9; Copyright (c) 2008 Springer Science+Business Media, LLC; ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
INFANTS
NEONATES
PLASMINOGEN
REVIEWS
THROMBOSIS
VEINS
AGE GROUPS
ANIMALS
BLOOD COAGULATION FACTORS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHILDREN
DISEASES
DOCUMENT TYPES
DRUGS
FIBRINOLYTIC AGENTS
HEMATOLOGIC AGENTS
MAMMALS
MAN
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
VASCULAR DISEASES
VERTEBRATES