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Title: Exeresis and Brachytherapy as Salvage Treatment for Local Recurrence After Conservative Treatment for Breast Cancer: Results of a Ten-Year Pilot Study

Abstract

Purpose: To analyze the long-term results of a pilot study assessing excision and brachytherapy as salvage treatment for local recurrence after conservative treatment of breast cancer. Methods and Materials: Between December 1990 and March 2001, 36 patients with breast-only recurrence less than 3 cm in diameter after conservative treatment for Stage I or II breast carcinoma were treated with local excision followed by high-dose rate brachytherapy implants (30 Gy in 12 fractions over a period of 5 days). No patient was lost to follow-up. Special attention was paid to local, regional, or distant recurrences; survival; cosmesis; and early and late side effects. Results: All patients completed treatment. During follow-up (range, 1-13 years), 8 patients presented metastases (2 regional and 6 distant) as their first site of failure, 1 had a differed local recurrence, and 1 died of the disease. Actuarial results at 10 years were as follows: local control, 89.4%; disease-free survival, 64.4%; and survival, 96.7%. Cosmetic results were satisfactory in 90.4%. No patient had Grade 3 or 4 early or late complications. Of the 11 patients followed up for at least 10 years, all but 1 still had their breast in place at the 10-year stage. Conclusions: High-dose ratemore » brachytherapy is a safe, effective treatment for small-size, low-risk local recurrence after local excision in conservatively treated patients. The dose of 30 Gy of high-dose rate brachytherapy (12 fractions over a period of 5 days twice daily) was well tolerated. The excellent results support the use of breast preservation as salvage treatment in selected patients with local recurrence after conservative treatment for breast cancer.« less

Authors:
 [1]; ; ; ; ; ; ; ; ; ; ;  [2]
  1. IMOR Foundation, Medical Institute for Radiotherapy and Oncology, Barcelona (Spain) and Universitat de Barcelona, Barcelona (Spain)
  2. IMOR Foundation, Medical Institute for Radiotherapy and Oncology, Barcelona, Spain, and Universitat de Barcelona, Barcelona (Spain)
Publication Date:
OSTI Identifier:
21438012
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 78; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2009.08.009; PII: S0360-3016(09)02941-1; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRACHYTHERAPY; CARCINOMAS; DOSE RATES; FRACTIONATED IRRADIATION; IMPLANTS; MAMMARY GLANDS; BODY; DISEASES; GLANDS; IRRADIATION; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RADIOTHERAPY; THERAPY

Citation Formats

Guix, Benjamin, E-mail: bguix@imor.or, Lejarcegui, Jose Antonio, Tello, Jose Ignacio, Zanon, Gabriel, Henriquez, Ivan, Finestres, Fernando, Martinez, Antonio, Fernandez-Ibiza, Jaume, Quinzanos, Luis, Palombo, Pau, Encinas, Xavier, and Guix, Ines. Exeresis and Brachytherapy as Salvage Treatment for Local Recurrence After Conservative Treatment for Breast Cancer: Results of a Ten-Year Pilot Study. United States: N. p., 2010. Web. doi:10.1016/j.ijrobp.2009.08.009.
Guix, Benjamin, E-mail: bguix@imor.or, Lejarcegui, Jose Antonio, Tello, Jose Ignacio, Zanon, Gabriel, Henriquez, Ivan, Finestres, Fernando, Martinez, Antonio, Fernandez-Ibiza, Jaume, Quinzanos, Luis, Palombo, Pau, Encinas, Xavier, & Guix, Ines. Exeresis and Brachytherapy as Salvage Treatment for Local Recurrence After Conservative Treatment for Breast Cancer: Results of a Ten-Year Pilot Study. United States. doi:10.1016/j.ijrobp.2009.08.009.
Guix, Benjamin, E-mail: bguix@imor.or, Lejarcegui, Jose Antonio, Tello, Jose Ignacio, Zanon, Gabriel, Henriquez, Ivan, Finestres, Fernando, Martinez, Antonio, Fernandez-Ibiza, Jaume, Quinzanos, Luis, Palombo, Pau, Encinas, Xavier, and Guix, Ines. Mon . "Exeresis and Brachytherapy as Salvage Treatment for Local Recurrence After Conservative Treatment for Breast Cancer: Results of a Ten-Year Pilot Study". United States. doi:10.1016/j.ijrobp.2009.08.009.
@article{osti_21438012,
title = {Exeresis and Brachytherapy as Salvage Treatment for Local Recurrence After Conservative Treatment for Breast Cancer: Results of a Ten-Year Pilot Study},
author = {Guix, Benjamin, E-mail: bguix@imor.or and Lejarcegui, Jose Antonio and Tello, Jose Ignacio and Zanon, Gabriel and Henriquez, Ivan and Finestres, Fernando and Martinez, Antonio and Fernandez-Ibiza, Jaume and Quinzanos, Luis and Palombo, Pau and Encinas, Xavier and Guix, Ines},
abstractNote = {Purpose: To analyze the long-term results of a pilot study assessing excision and brachytherapy as salvage treatment for local recurrence after conservative treatment of breast cancer. Methods and Materials: Between December 1990 and March 2001, 36 patients with breast-only recurrence less than 3 cm in diameter after conservative treatment for Stage I or II breast carcinoma were treated with local excision followed by high-dose rate brachytherapy implants (30 Gy in 12 fractions over a period of 5 days). No patient was lost to follow-up. Special attention was paid to local, regional, or distant recurrences; survival; cosmesis; and early and late side effects. Results: All patients completed treatment. During follow-up (range, 1-13 years), 8 patients presented metastases (2 regional and 6 distant) as their first site of failure, 1 had a differed local recurrence, and 1 died of the disease. Actuarial results at 10 years were as follows: local control, 89.4%; disease-free survival, 64.4%; and survival, 96.7%. Cosmetic results were satisfactory in 90.4%. No patient had Grade 3 or 4 early or late complications. Of the 11 patients followed up for at least 10 years, all but 1 still had their breast in place at the 10-year stage. Conclusions: High-dose rate brachytherapy is a safe, effective treatment for small-size, low-risk local recurrence after local excision in conservatively treated patients. The dose of 30 Gy of high-dose rate brachytherapy (12 fractions over a period of 5 days twice daily) was well tolerated. The excellent results support the use of breast preservation as salvage treatment in selected patients with local recurrence after conservative treatment for breast cancer.},
doi = {10.1016/j.ijrobp.2009.08.009},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 3,
volume = 78,
place = {United States},
year = {Mon Nov 01 00:00:00 EDT 2010},
month = {Mon Nov 01 00:00:00 EDT 2010}
}