Disturbed Colonic Motility Contributes to Anorectal Symptoms and Dysfunction After Radiotherapy for Carcinoma of the Prostate

Journal Article · Mon Nov 01 04:00:00 EDT 2010 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2009.08.050· OSTI ID:21438008

Bartholomeusz, Dylan L ^[1]; Holloway, Richard H ^[2]; Fraser, Robert J ^[3]; Botten, Rochelle; Di Matteo, Addolorata ^[4]; Moore, James W ^[5]; Schoeman, Mark N ^[2]

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1. Department of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, SA (Australia)
2. Department of Gastroenterology, Royal Adelaide Hospital, Adelaide, SA (Australia)
3. Gastrointestinal Investigation Unit, Repatriation General Hospital, Daw Park, SA (Australia)
4. Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, SA (Australia)
5. Department of Colorectal Surgery, Royal Adelaide Hospital, Adelaide, SA (Australia)

Purpose: To evaluate the role of colonic motility in the pathogenesis of anorectal symptoms and dysfunction after radiotherapy (RT) for carcinoma of the prostate. Patients and Methods: Thirty-eight patients, median age 71 (range, 50-81) years with localized prostate carcinoma randomized to one of two radiation dose schedules underwent colonic transit scintigraphy and assessment of anorectal symptoms (questionnaire), anorectal function (manometry), and anal sphincteric morphology (endoanal ultrasound) before and at 1 month and 1 year after RT. Results: Whole and distal colonic transit increased 1 month after RT, with faster distal colonic transit only persisting at 1 year. Frequency and urgency of defecation, fecal incontinence, and rectal bleeding increased 1 month after RT and persisted at 1 year. Basal anal pressures remained unchanged, but progressive reductions occurred in anal squeeze pressures and responses to increased intra-abdominal pressure. Rectal compliance decreased progressively in the patients, although no changes in anorectal sensory function ensued. Radiotherapy had no effect on the morphology of the internal and external anal sphincters. Distal colonic retention was weakly related to rectal compliance at 1 month, but both faster colonic transit and reduced rectal compliance were more frequent with increased fecal urgency. At 1 year, a weak inverse relationship existed between colonic half-clearance time and frequency of defecation, although both faster whole-colonic transit and reduced rectal compliance occurred more often with increased stool frequency. Conclusion: Colonic dysmotility contributes to anorectal dysfunction after RT for carcinoma of the prostate. This has implications for improving the management of anorectal radiation sequelae.

• OSTI ID: 21438008
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 78; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
CARCINOMAS
COMPLIANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
GLANDS
INTESTINES
LARGE INTESTINE
MALE GENITALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOGENESIS
PROSTATE
RADIOISOTOPE SCANNING
RADIOLOGY
RADIOTHERAPY
RECTUM
SCINTISCANNING
SYMPTOMS
THERAPY