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Title: CT Fluoroscopy-Guided Lung Biopsy with Novel Steerable Biopsy Canula: Ex-Vivo Evaluation in Ventilated Porcine Lung Explants

Abstract

The purpose was to evaluate ex-vivo a prototype of a novel biopsy canula under CT fluoroscopy-guidance in ventilated porcine lung explants in respiratory motion simulations. Using an established chest phantom for porcine lung explants, n = 24 artificial lesions consisting of a fat-wax-Lipiodol mixture (approx. 70HU) were placed adjacent to sensible structures such as aorta, pericardium, diaphragm, bronchus and pulmonary artery. A piston pump connected to a reservoir beneath a flexible silicone reconstruction of a diaphragm simulated respiratory motion by rhythmic inflation and deflation of 1.5 L water. As biopsy device an 18-gauge prototype biopsy canula with a lancet-like, helically bended cutting edge was used. The artificial lesions were punctured under CT fluoroscopy-guidance (SOMATOM Sensation 64, Siemens, Erlangen, Germany; 30mAs/120 kV/5 mm slice thickness) implementing a dedicated protocol for CT fluoroscopy-guided lung biopsy. The mean-diameter of the artificial lesions was 8.3 {+-} 2.6 mm, and the mean-distance of the phantom wall to the lesions was 54.1 {+-} 13.5 mm. The mean-displacement of the lesions by respiratory motion was 14.1 {+-} 4.0 mm. The mean-duration of CT fluoroscopy was 9.6 {+-} 5.1 s. On a 4-point scale (1 = central; 2 = peripheral; 3 = marginal; 4 = off target), themore » mean-targeted precision was 1.9 {+-} 0.9. No misplacement of the biopsy canula affecting adjacent structures could be detected. The novel steerable biopsy canula proved to be efficient in the ex-vivo set-up. The chest phantom enabling respiratory motion and the steerable biopsy canula offer a feasible ex-vivo system for evaluating and training CT fluoroscopy-guided lung biopsy adapted to respiratory motion.« less

Authors:
; ; ; ;  [1];  [2];  [1]
  1. University Hospital Schleswig-Holstein Campus Kiel, Department of Diagnostic Radiology (Germany)
  2. Medical University of Vienna, Department of Radiology, Division of Cardiovascular and Interventional Radiology (Austria)
Publication Date:
OSTI Identifier:
21428955
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 33; Journal Issue: 4; Other Information: DOI: 10.1007/s00270-009-9771-8; Copyright (c) 2010 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AORTA; BIOPSY; CHEST; DIAPHRAGM; FLUOROSCOPY; LIPIODOL; LUNGS; PERICARDIUM; PHANTOMS; RESPIRATION; SIMULATION; TUBES; ARTERIES; BIOMEDICAL RADIOGRAPHY; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; CONTRAST MEDIA; DIAGNOSTIC TECHNIQUES; HEART; MEDICINE; MEMBRANES; MOCKUP; MUSCLES; NUCLEAR MEDICINE; OILS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; OTHER ORGANIC COMPOUNDS; RADIOLOGY; RESPIRATORY SYSTEM; SEROUS MEMBRANES; STRUCTURAL MODELS

Citation Formats

Schaefer, Philipp J., E-mail: jp.schaefer@rad.uni-kiel.de, Fabel, Michael, Bolte, Hendrik, Schaefer, Fritz K. W., Jahnke, Thomas, Heller, Martin, Lammer, Johannes, and Biederer, Juergen. CT Fluoroscopy-Guided Lung Biopsy with Novel Steerable Biopsy Canula: Ex-Vivo Evaluation in Ventilated Porcine Lung Explants. United States: N. p., 2010. Web. doi:10.1007/S00270-009-9771-8.
Schaefer, Philipp J., E-mail: jp.schaefer@rad.uni-kiel.de, Fabel, Michael, Bolte, Hendrik, Schaefer, Fritz K. W., Jahnke, Thomas, Heller, Martin, Lammer, Johannes, & Biederer, Juergen. CT Fluoroscopy-Guided Lung Biopsy with Novel Steerable Biopsy Canula: Ex-Vivo Evaluation in Ventilated Porcine Lung Explants. United States. doi:10.1007/S00270-009-9771-8.
Schaefer, Philipp J., E-mail: jp.schaefer@rad.uni-kiel.de, Fabel, Michael, Bolte, Hendrik, Schaefer, Fritz K. W., Jahnke, Thomas, Heller, Martin, Lammer, Johannes, and Biederer, Juergen. Sun . "CT Fluoroscopy-Guided Lung Biopsy with Novel Steerable Biopsy Canula: Ex-Vivo Evaluation in Ventilated Porcine Lung Explants". United States. doi:10.1007/S00270-009-9771-8.
@article{osti_21428955,
title = {CT Fluoroscopy-Guided Lung Biopsy with Novel Steerable Biopsy Canula: Ex-Vivo Evaluation in Ventilated Porcine Lung Explants},
author = {Schaefer, Philipp J., E-mail: jp.schaefer@rad.uni-kiel.de and Fabel, Michael and Bolte, Hendrik and Schaefer, Fritz K. W. and Jahnke, Thomas and Heller, Martin and Lammer, Johannes and Biederer, Juergen},
abstractNote = {The purpose was to evaluate ex-vivo a prototype of a novel biopsy canula under CT fluoroscopy-guidance in ventilated porcine lung explants in respiratory motion simulations. Using an established chest phantom for porcine lung explants, n = 24 artificial lesions consisting of a fat-wax-Lipiodol mixture (approx. 70HU) were placed adjacent to sensible structures such as aorta, pericardium, diaphragm, bronchus and pulmonary artery. A piston pump connected to a reservoir beneath a flexible silicone reconstruction of a diaphragm simulated respiratory motion by rhythmic inflation and deflation of 1.5 L water. As biopsy device an 18-gauge prototype biopsy canula with a lancet-like, helically bended cutting edge was used. The artificial lesions were punctured under CT fluoroscopy-guidance (SOMATOM Sensation 64, Siemens, Erlangen, Germany; 30mAs/120 kV/5 mm slice thickness) implementing a dedicated protocol for CT fluoroscopy-guided lung biopsy. The mean-diameter of the artificial lesions was 8.3 {+-} 2.6 mm, and the mean-distance of the phantom wall to the lesions was 54.1 {+-} 13.5 mm. The mean-displacement of the lesions by respiratory motion was 14.1 {+-} 4.0 mm. The mean-duration of CT fluoroscopy was 9.6 {+-} 5.1 s. On a 4-point scale (1 = central; 2 = peripheral; 3 = marginal; 4 = off target), the mean-targeted precision was 1.9 {+-} 0.9. No misplacement of the biopsy canula affecting adjacent structures could be detected. The novel steerable biopsy canula proved to be efficient in the ex-vivo set-up. The chest phantom enabling respiratory motion and the steerable biopsy canula offer a feasible ex-vivo system for evaluating and training CT fluoroscopy-guided lung biopsy adapted to respiratory motion.},
doi = {10.1007/S00270-009-9771-8},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 4,
volume = 33,
place = {United States},
year = {2010},
month = {8}
}