Ischemic Effects of Transcatheter Arterial Embolization with N-Butyl Cyanoacrylate-Lipiodol on the Colon in a Swine Model

Journal Article · Fri Oct 15 00:00:00 EDT 2010 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-010-9867-1· OSTI ID:21428913

Ikoma, Akira; Kawai, Nobuyuki; Sato, Morio; Sonomura, Tetsuo; Minamiguchi, Hiroki; Nakai, Motoki; Takasaka, Isao; Nakata, Kouhei; Sahara, Shinya; Sawa, Naohisa; Shirai, Shintaro ^[1]; Mori, Ichiro ^[2]

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1. Wakayama Medical University, Department of Radiology (Japan)
2. Wakayama Medical University, Second Department of Pathology (Japan)

This study was designed to assess the safety of transcatheter arterial embolization (TAE) with n-butyl cyanoacrylate-lipiodol (NBCA-Lp) for the large bowel and to investigate the vital response to NBCA-Lp in a swine model. In nine swine, nine arteries nourishing the colon were embolized with NBCA-Lp (1 ml of NBCA mixed with 4 ml of lipiodol): sigmoid-rectal branch artery in six swine, right colic branch artery in two, and middle colic branch artery in one. The amount of NBCA-Lp was 0.1-0.4 ml. Sacrifice was conducted 3 days after TAE to identify histological infarction. Classification was conducted retrospectively: group A, vasa recta without NBCA-Lp embolization despite TAE; group B, three or fewer vasa recta with NBCA-Lp embolization; and group C, five or more vasa recta with NBCA-Lp embolization. In one swine in group A, no necrotic focus was observed. In group B, three of four swine experienced no ischemic damage. The remaining one swine experienced necrosis of mucosal and submucosal layers in one-fourth of the circumference. In group C, all four swine with marginal artery and five vasa recta or more embolized experienced total necrosis of mucosa, submucosa, and smooth muscle layers of the whole colonic circumference. Significant difference on the extent of ischemic damage was observed between groups B and C (P < 0.05). Microscopically, NBCA-Lp induced acute vasculitis. Embolization of three or fewer vasa recta with NBCA-Lp induced no ischemic damage or limited necrosis, whereas embolization of five or more vasa recta with NBCA-Lp induced extensive necrosis.

• OSTI ID: 21428913
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 33, Issue 5; Other Information: DOI: 10.1007/s00270-010-9867-1; Copyright (c) 2010 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ACRYLATES
ARTERIES
DAMAGE
EMBOLI
ISCHEMIA
LIPIODOL
NECROSIS
RECTUM
SWINE
TUBES
ANEMIAS
ANIMALS
BLOOD VESSELS
BODY
CARBOXYLIC ACID SALTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CONTRAST MEDIA
DIGESTIVE SYSTEM
DISEASES
DOMESTIC ANIMALS
GASTROINTESTINAL TRACT
HEMIC DISEASES
INTESTINES
LARGE INTESTINE
MAMMALS
OILS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES