Ultrashort Pulse Laser Accelerated Proton Beams for First Radiobiological Applications

Journal Article · Thu Nov 04 00:00:00 EDT 2010 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3520421· OSTI ID:21428866

Schramm, U; Zeil, K; Beyreuther, E; Bussmann, M; Cowan, T E; Kluge, T; Kraft, S; Metzkes, J; Sauerbrey, R ^[1]; Richter, C; Enghardt, W; Pawelke, J ^[2]; Karsch, L; Laschinsky, L; Naumburger, D ^[2]

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1. Forschungszentrum Dresden-Rossendorf (FZD), Bautzner Landstrasse 400, 01328 Dresden (Germany)
2. OncoRay- Center for Radiation Research in Oncology, TU Dresden, Fetscherstr. 74, 01307 Dresden (Germany)

We report on the generation of proton pulses with maximum energies exceeding 15 MeV by means of the irradiation of few micron thick metal foils by ultrashort (30 fs) laser pulses at a power level of 100 TW. In contrast to the well known situation for longer laser pulses, here, a near linear scaling of the maximum proton energy with laser power can be found. Aiming for radiobiological applications the long and short term stability of the laser plasma accelerator as well as a compact energy selection and dosimetry system is presented. The first irradiation of in vitro tumour cells showing dose dependent biological damage is demonstrated paving the way for systematic radiobiological studies.

• OSTI ID: 21428866
• Journal Information: AIP Conference Proceedings, Vol. 1299, Issue 1; Conference: 14. advanced accelerator concepts workshop, Annapolis, MD (United States), 13-19 Jun 2010; Other Information: DOI: 10.1063/1.3520421; (c) 2010 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

43 PARTICLE ACCELERATORS
ACCELERATION
BEAM PRODUCTION
BEAM TRANSPORT
BEAM-PLASMA SYSTEMS
DOSIMETRY
FOILS
LASER TARGETS
LASER-PRODUCED PLASMA
LASERS
MEV RANGE
PLASMA GUNS
PROTON BEAMS
PULSED IRRADIATION
PULSES
RADIOTHERAPY
BEAMS
ENERGY RANGE
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
NUCLEON BEAMS
PARTICLE BEAMS
PLASMA
RADIOLOGY
TARGETS
THERAPY