Early Detection of Therapeutic Response to Hepatic Arterial Infusion Chemotherapy of Liver Metastases from Colorectal Cancer Using Diffusion-Weighted MR Imaging

Journal Article · Wed Jul 15 04:00:00 EDT 2009 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-009-9532-8· OSTI ID:21428507

Marugami, Nagaaki; Tanaka, Toshihiro; Kitano, Satoru ^[1]; Hirohashi, Shinji ^[2]; Nishiofuku, Hideyuki ^[1]; Takahashi, Aki; Sakaguchi, Hiroshi ^[3]; Matsuoka, Masaki; Otsuji, Toshio ^[4]; Takahama, Junko; Higashiura, Wataru; Kichikawa, Kimihiko ^[1]

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1. Nara Medical University, Department of Radiology (Japan)
2. Osaka Gyomeikan Hospital, Department of Radiology (Japan)
3. Nara Prefectural Mimuro Hospital, Department of Radiology (Japan)
4. Dongo Hospital, Department of Gastrointestinal Medicine (Japan)

The purpose of this study was to investigate whether diffusion-weighted magnetic resonance imaging (DWI) is useful for early detection of the response of hepatic colorectal metastases to hepatic arterial infusion chemotherapy (HAIC) with 5-fluorouracil (5-FU). The subjects were 12 patients with hepatic colorectal metastases. The indwelling catheter for HAIC was placed in the hepatic artery, and 1000 mg/m{sup 2} 5-FU was given repeatedly once a week. DWI was performed before and 9 days after HAIC. The minimum and mean apparent diffusion coefficient (ADC) values (minADC and meanADC) were measured. The relative change in ADC values (%ADC) and the relative change in tumor size on follow-up CT after 3 months (reduction ratio) were determined. Liver metastases were divided into two groups, responder and nonresponder. The correlation between %ADC and reduction ratio was determined, and %ADC was compared between the two groups. Eleven patients successfully completed HAIC over the 3-month period; 48 metastatic lesions were evaluated. Positive correlations were observed for relative change between %minADC and reduction ratio (r = 0.709) and between %meanADC and reduction ratio (r = 0.536). Both %minADC and %meanADC were significantly greater in the responder group than in the nonresponder group. With the threshold determined as < 3.5%, the receiver-operating curve analysis showed higher sensitivity and specificity values for %minADC (100% and 92.6%, respectively) than for %meanADC (66.7% and 74.1%, respectively). In conclusion, the relative change in minimum ADC values on DWI may be useful for early detection of the response of liver metastases to HAIC with 5-FU.

• OSTI ID: 21428507
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 4 Vol. 32; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
AZINES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CHEMOTHERAPY
DETECTION
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INFUSION
INTAKE
LIVER
MEDICINE
METASTASES
NEOPLASMS
NMR IMAGING
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
THERAPY
URACILS