Intraarterial infusion chemotherapy with lipioclol-CDDP suspension for hepatocellular carcinoma

Journal Article · Sat Jan 15 00:00:00 EST 2000 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S002709910005· OSTI ID:21414369

Yamamoto, Kazuhiro; Shimizu, Tadafumi; Narabayashi, Isamu ^[1]

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1. Osaka Medical College, Department of Radiology (Japan)

Purpose: To quantitatively evaluate the usefulness of lipiodol-CDDP suspension (LCS) chemotherapy in hepatocellular carcinoma (HCC).Methods: CDDP (cis-diamminedichloroplatinum) powder was prepared by removing the water and NaCl from aqueous CDDP. Two quantities of prepared CDDP powder, 10 mg and 20 mg, were mixed with 1 ml each of iopamidol 300 mgl/ml (IP300) and lipiodol (LPD) using a high pressure pumping method, thus producing LCS. Thirty-two patients with HCC, who had good renal function [creatinine clearance (Ccr) 50 ml/min or more], received additional intraarterial infusion chemotherapy with LCS or LCS alone.Results: The most frequently observed CDDP powder sizes were 5.95-10.90 {mu}m (average: 11.59 {mu}m). The LCS obtained demonstrated a suspension of 2-12 {mu}m (average 3.69 {mu}m) immediately after mixing, and no significant changes were observed in LCS particle sizes 3 hr after mixing. Moreover, the sustained release with LCS was observed for up to 3 hr. Meanwhile, the peripheral free platinum concentration between intraarterial infusion chemotherapy with LCS and intraarterial infusion with the aqueous solution of CDDP, with respect to variance residence time (VRT), showed a significant difference, with a p value of 0.0382. The survival rate was 89.84% at 1 year, 73.787c at 2 years, and 68.51% at 3 years. Furthermore, the platinum concentration in the tumor was 25-95 times the concentration in the surrounding liver parenchyma.Conclusion: Good clinical results can be expected by applying LCS to HCC.

• OSTI ID: 21414369
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 23, Issue 1; Other Information: DOI: 10.1007/s002709910005; Copyright (c) 2000 Springer-Verlag; Article Copyright (c) 2000 Springer-Verlag New York, Inc; ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CHEMOTHERAPY
HEPATOMAS
INFUSION
IOPAMIDOL
LIPIODOL
LIVER
PLATINUM COMPLEXES
BODY
CARCINOMAS
COMPLEXES
CONTRAST MEDIA
DIGESTIVE SYSTEM
DISEASES
GLANDS
INTAKE
MEDICINE
NEOPLASMS
OILS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
THERAPY
TRANSITION ELEMENT COMPLEXES