Toxicity Associated With Bowel or Bladder Puncture During Gynecologic Interstitial Brachytherapy
Journal Article
·
· International Journal of Radiation Oncology, Biology and Physics
- Department of Radiation Oncology, Rush University, Chicago, IL (United States)
Purpose: Interstitial brachytherapy for gynecologic malignancies is associated with significant toxicity. Some reports have correlated this toxicity with needle puncture of the visceral organs. This study examined our experience with interstitial brachytherapy and investigated the relationship between the visceral puncture and toxicity. Methods and Materials: The outcomes of 36 patients treated with interstitial brachytherapy for gynecologic malignancies at a single institution between 2002 and 2007 were reviewed. Computed tomography was used to guide needle placement based solely on tumor coverage. No attempts were made to avoid visceral puncture; however, the source dwell times were minimized in these areas. Results: At a median follow-up of 21 months, the crude locoregional control rate was 78%. Bowel puncture was noted in 26 patients and bladder puncture in 19. The mean operating time was 50 min, and 86% of patients were discharged in <=3 days. The incidence of acute and late toxicity was similar between patients with and without visceral puncture according to the log-rank analysis of Kaplan-Meier curves. No patients with bowel puncture experienced Grade 2 or greater acute gastrointestinal toxicity and only 1 had Grade 3 or greater late gastrointestinal toxicity. No patients with bladder puncture experienced greater than Grade 2 acute genitourinary toxicity and only 2 had late Grade 3 or greater genitourinary toxicity. Conclusion: The operating time, length of hospital stay, and treatment-induced morbidity in this cohort compared favorably to series using techniques to avoid visceral puncture. Additionally, visceral puncture did not correlate with the occurrence of acute or late toxicity. These data suggest that visceral puncture in the absence of source loading carries a low risk of morbidity.
- OSTI ID:
- 21372257
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 1 Vol. 77; ISSN IOBPD3; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
Similar Records
A phase II study of external beam radiotherapy combined with permanent source brachytherapy for intermediate-risk, clinically localized adenocarcinoma of the prostate: Preliminary results of RTOG P-0019
Hypofractionated Intensity Modulated Radiation Therapy in Combined Modality Treatment for Bladder Preservation in Elderly Patients With Invasive Bladder Cancer
Whole pelvic radiotherapy for prostate cancer using 3D conformal and intensity-modulated radiotherapy
Journal Article
·
Tue Feb 28 23:00:00 EST 2006
· International Journal of Radiation Oncology, Biology and Physics
·
OSTI ID:20793349
Hypofractionated Intensity Modulated Radiation Therapy in Combined Modality Treatment for Bladder Preservation in Elderly Patients With Invasive Bladder Cancer
Journal Article
·
Fri Jan 31 23:00:00 EST 2014
· International Journal of Radiation Oncology, Biology and Physics
·
OSTI ID:22283346
Whole pelvic radiotherapy for prostate cancer using 3D conformal and intensity-modulated radiotherapy
Journal Article
·
Mon Oct 31 23:00:00 EST 2005
· International Journal of Radiation Oncology, Biology and Physics
·
OSTI ID:20702191