Tumor Volume Changes Assessed by Three-Dimensional Magnetic Resonance Volumetry in Rectal Cancer Patients After Preoperative Chemoradiation: The Impact of the Volume Reduction Ratio on the Prediction of Pathologic Complete Response

Journal Article · Mon Mar 15 04:00:00 EDT 2010 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2009.03.066· OSTI ID:21372155

Kang, Jeong Hyun ^[1]; Kim, Young Chul ^[2]; Kim, Hyunki ^[3]; Kim, Young Wan; Hur, Hyuk; Kim, Jin Soo; Min, Byung Soh ^[1]; Kim, Hogeun ^[3]; Lim, Joon Seok ^[2]; Seong, Jinsil; Keum, Ki Chang ^[4]

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1. Department of Surgery, Yonsei University Health System, Yonsei University College of Medicine, Seoul (Korea, Republic of)
2. Department of Radiology, Yonsei University Health System, Yonsei University College of Medicine, Seoul (Korea, Republic of)
3. Department of Pathology, Yonsei University Health System, Yonsei University College of Medicine, Seoul (Korea, Republic of)
4. Department of Radiation Oncology, Yonsei University Health System, Yonsei University College of Medicine, Seoul (Korea, Republic of)

Purpose: The aim of this study was to determine the correlation between tumor volume changes assessed by three-dimensional (3D) magnetic resonance (MR) volumetry and the histopathologic tumor response in rectal cancer patients undergoing preoperative chemoradiation therapy (CRT). Methods and Materials: A total of 84 patients who underwent preoperative CRT followed by radical surgery were prospectively enrolled in the study. The post-treatment tumor volume and tumor volume reduction ratio (% decrease ratio), as shown by 3D MR volumetry, were compared with the histopathologic response, as shown by T and N downstaging and the tumor regression grade (TRG). Results: There were no significant differences in the post-treatment tumor volume and the volume reduction ratio shown by 3D MR volumetry with respect to T and N downstaging and the tumor regression grade. In a multivariate analysis, the tumor volume reduction ratio was not significantly associated with T and N downstaging. The volume reduction ratio (>75%, p = 0.01) and the pretreatment carcinoembryonic antigen level (<=3 ng/ml, p = 0.01), but not the post-treatment volume shown by 3D MR (<= 5ml), were, however, significantly associated with an increased pathologic complete response rate. Conclusion: More than 75% of the tumor volume reduction ratios were significantly associated with a high pathologic complete response rate. Therefore, limited treatment options such as local excision or simple observation might be considered after preoperative CRT in this patient population.

• OSTI ID: 21372155
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 4 Vol. 76; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
CHEMOTHERAPY
CORRELATIONS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
INTESTINES
LARGE INTESTINE
MEDICINE
NEOPLASMS
NMR IMAGING
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
RADIOTHERAPY
RECTUM
SHRINKAGE
SIZE
SURGERY
THERAPY
THREE-DIMENSIONAL CALCULATIONS