Radiation-Associated Kidney Injury

Journal Article · Mon Mar 01 00:00:00 EST 2010 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2009.02.089· OSTI ID:21372138

Kavanagh, Brian D ^[1]; Paulino, Arnold C ^[2]; Das, Shiva K ^[3]; Miften, Moyed ^[1]; Li, X Allen ^[4]; Pan, Charlie; Ten Haken, Randall K ^[5]; Schultheiss, Timothy E ^[6]

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1. Department of Radiation Oncology, University of Colorado, Denver, CO (United States)
2. Department of Radiology, Division of Radiation Oncology, Baylor College of Medicine and Methodist Hospital, Houston, TX (United States)
3. Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)
4. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States)
5. Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI (United States)
6. Department of Radiation Oncology, City of Hope Medical Center and Beckman Research Institute, Duarte, CA (United States)

The kidneys are the dose-limiting organs for radiotherapy to upper abdominal cancers and during total body irradiation. The incidence of radiotherapy-associated kidney injury is likely underreported owing to its long latency and because the toxicity is often attributed to more common causes of kidney injury. The pathophysiology of radiation injury is poorly understood. Its presentation can be acute and irreversible or subtle, with a gradual progressive dysfunction over years. A variety of dose and volume parameters have been associated with renal toxicity and are reviewed to provide treatment guidelines. The available predictive models are suboptimal and require validation. Mitigation of radiation nephropathy with angiotensin-converting enzyme inhibitors and other compounds has been shown in animal models and, more recently, in patients.

• OSTI ID: 21372138
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 76, Issue 3; Other Information: DOI: 10.1016/j.ijrobp.2009.02.089; PII: S0360-3016(09)03282-9; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANGIOTENSIN
ENZYME INHIBITORS
KIDNEYS
MITIGATION
NEOPLASMS
RADIATION DOSES
RADIATION INJURIES
RADIOTHERAPY
TOXICITY
WHOLE-BODY IRRADIATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR AGENTS
DISEASES
DOSES
DRUGS
EXTERNAL IRRADIATION
GLOBULINS
INJURIES
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RADIOLOGY
THERAPY
VASOCONSTRICTORS