Early Hyperbaric Oxygen Therapy for Reducing Radiotherapy Side Effects: Early Results of a Randomized Trial in Oropharyngeal and Nasopharyngeal Cancer

Journal Article · Sun Nov 01 04:00:00 EST 2009 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2008.11.056· OSTI ID:21362205

Teguh, David N ^[1]; Noever, Inge; Voet, Peter; Est, Henrie van der; Rooij, Peter van ^[1]; Dumans, Antoine G ^[2]; Boer, Maarten F. de ^[3]; Huls, Michiel van der; Sterk, Wouter ^[4]; Schmitz, Paul ^[5]

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1. Department of Radiation Oncology, Rotterdam (Netherlands)
2. Department of Maxillofacial Surgery, Rotterdam (Netherlands)
3. Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam (Netherlands)
4. Institute for Hyperbaric Medicine, Rotterdam (Netherlands)
5. Department of Biostatistics of Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands)

Purpose: Comparison of quality of life (QoL) and side effects in a randomized trial for early hyperbaric oxygen therapy (HBOT) after radiotherapy (RT). Methods and Materials: From 2006, 19 patients with tumor originating from the tonsillar fossa and/or soft palate (15), base of tongue (1), and nasopharynx (3) were randomized to receive HBOT or not. HBOT consisted of 30 sessions at 2.5 ATA (15 msw) with oxygen breathing for 90 min daily, 5 days per week, applied shortly after the RT treatment was completed. As of 2005, all patients received validated questionnaires (i.e., the European Organization for Research and Treatment of Cancer [EORTC] QLQ-C30, EORTC QLQ Head and Neck Cancer Module (H and N35), Performance Status Scale): before treatment; at the start of RT treatment; after 46 Gy; at the end of RT treatment; and 2, 4, and 6 weeks and 3, 6, 12, and 18 months after follow-up. Results: On all QoL items, better scores were obtained in patients treated with hyperbaric oxygen. The difference between HBOT vs. non-HBOT was significant for all parameters: EORTC H and N35 Swallowing (p = 0.011), EORTC H and N35 Dry Mouth (p = 0.009), EORTC H and N35, Sticky Saliva (p = 0.01), PSS Eating in Public (p = 0.027), and Pain in Mouth (visual analogue scale; p < 0.0001). Conclusions: Patients randomized for receiving hyperbaric oxygen after the RT had better QoL scores for swallowing, sticky saliva, xerostomia, and pain in mouth.

• OSTI ID: 21362205
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 75; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
MEDICINE
NEOPLASMS
NONMETALS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
OXYGEN
PHARYNX
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
TONGUE