Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction

Journal Article · Mon Feb 15 00:00:00 EST 2010 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2009.11.016· OSTI ID:21344869

Jun, Deng ^[1]; Chunsheng, Liu; Liqin, Yu ^[1]

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1. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072 (China)

Tribromophenol (2,4,6-TBP) is ubiquitously found in aquatic environments and biota. In this study, we exposed zebrafish embryos (F{sub 0}; 2'''' days post-fertilization, dpf) to environmental concentration (0.3 mug/L) and a higher concentration (3.0 mug/L) of TBP and assessed the impact of chronic exposure (120 dpf) on reproduction. TBP exposure did not cause a significant increase in the malformation and reduction in the survival in the F{sub 0}-generation fish. After TBP exposure, the plasma testosterone and estradiol levels significantly increased in males and decreased in females. The transcription of steroidogenic genes (3beta-HSD, 17beta-HSD, CYP17, CYP19A, CYP19B) was significantly upregulated in the brain and testes in males and downregulated in the brain and ovary in females. TBP exposure significantly downregulated and upregulated the expression of VTG in the liver of female and male fish, respectively. Meanwhile, TBP exposure altered the sex ratio toward a male-dominant state. The F{sub 1}-generation larvae exhibited increased malformation, reduced survival, and retarded growth, suggesting that TBP in the aquatic environment has significant adverse effects on fish population.

• OSTI ID: 21344869
• Journal Information: Toxicology and Applied Pharmacology, Vol. 243, Issue 1; Other Information: DOI: 10.1016/j.taap.2009.11.016; PII: S0041-008X(09)00482-7; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BRAIN
BROMINATED AROMATIC HYDROCARBONS
CHRONIC EXPOSURE
EMBRYOS
ESTRADIOL
FERTILIZATION
FISHES
LIVER
MALFORMATIONS
OVARIES
PHENOLS
REPRODUCTION
TESTES
TESTOSTERONE
ANDROGENS
ANDROSTANES
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BODY
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
ESTRANES
ESTROGENS
FEMALE GENITALS
GLANDS
GONADS
HALOGENATED AROMATIC HYDROCARBONS
HORMONES
HYDROXY COMPOUNDS
KETONES
MALE GENITALS
NERVOUS SYSTEM
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
STEROID HORMONES
STEROIDS
VERTEBRATES