Bayesian population analysis of a washin-washout physiologically based pharmacokinetic model for acetone
- Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm (Sweden)
The aim of this study was to derive improved estimates of population variability and uncertainty of physiologically based pharmacokinetic (PBPK) model parameters, especially of those related to the washin-washout behavior of polar volatile substances. This was done by optimizing a previously published washin-washout PBPK model for acetone in a Bayesian framework using Markov chain Monte Carlo simulation. The sensitivity of the model parameters was investigated by creating four different prior sets, where the uncertainty surrounding the population variability of the physiological model parameters was given values corresponding to coefficients of variation of 1%, 25%, 50%, and 100%, respectively. The PBPK model was calibrated to toxicokinetic data from 2 previous studies where 18 volunteers were exposed to 250-550 ppm of acetone at various levels of workload. The updated PBPK model provided a good description of the concentrations in arterial, venous, and exhaled air. The precision of most of the model parameter estimates was improved. New information was particularly gained on the population distribution of the parameters governing the washin-washout effect. The results presented herein provide a good starting point to estimate the target dose of acetone in the working and general populations for risk assessment purposes.
- OSTI ID:
- 21344782
- Journal Information:
- Toxicology and Applied Pharmacology, Vol. 240, Issue 3; Other Information: DOI: 10.1016/j.taap.2009.07.033; PII: S0041-008X(09)00322-6; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0041-008X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach
Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: A case study with toluene
Related Subjects
ACCURACY
ACETONE
COMPUTERIZED SIMULATION
DOSES
MARKOV PROCESS
MEN
MONTE CARLO METHOD
OPTIMIZATION
RISK ASSESSMENT
SENSITIVITY
SENSITIVITY ANALYSIS
TOXICITY
WASHOUT
ANIMALS
CALCULATION METHODS
FALLOUT
KETONES
MALES
MAMMALS
MAN
ORGANIC COMPOUNDS
PRIMATES
SIMULATION
STOCHASTIC PROCESSES
VERTEBRATES