Feasibility of MRI-guided Focused Ultrasound as Organ-Sparing Treatment for Testicular Cancer
- Department of Medical Biophysics, University of Toronto (Canada)
- Imaging Research, Sunnybrook Health Sciences Centre 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 (Canada)
High cure rates for testicular cancer have prompted interest in organ-sparing surgery for patients with bilateral disease or single testis. Focused ultrasound (FUS) ablation could offer a noninvasive approach to organ-sparing surgery. The objective of this study was to determine the feasibility of using MR thermometry to guide organ-sparing focused ultrasound surgery in the testis. The testes of anesthetized rabbits were sonicated in several discrete locations using a single-element focused transducer operating at 2.787MHz. Focal heating was visualized with MR thermometry, using a measured PRF thermal coefficient of -0.0089{+-}0.0003 ppm/ deg. C. Sonications at 3.5-14 acoustic watts applied for 30 seconds produced maximum temperature elevations of 10-80 deg. C, with coagulation verified by histology. Coagulation of precise volumes in the testicle is feasible with MRI-guided focused ultrasound. Variability in peak temperature for given sonication parameters suggests the need for online temperature feedback control.
- OSTI ID:
- 21293551
- Journal Information:
- AIP Conference Proceedings, Vol. 1113, Issue 1; Conference: 8. international symposium on therapeutic ultrasound, Minneapolis, MN (United States), 10-13 Sep 2008; Other Information: DOI: 10.1063/1.3131398; (c) 2009 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
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