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Title: Feasibility of MRI-guided Focused Ultrasound as Organ-Sparing Treatment for Testicular Cancer

Abstract

High cure rates for testicular cancer have prompted interest in organ-sparing surgery for patients with bilateral disease or single testis. Focused ultrasound (FUS) ablation could offer a noninvasive approach to organ-sparing surgery. The objective of this study was to determine the feasibility of using MR thermometry to guide organ-sparing focused ultrasound surgery in the testis. The testes of anesthetized rabbits were sonicated in several discrete locations using a single-element focused transducer operating at 2.787MHz. Focal heating was visualized with MR thermometry, using a measured PRF thermal coefficient of -0.0089{+-}0.0003 ppm/ deg. C. Sonications at 3.5-14 acoustic watts applied for 30 seconds produced maximum temperature elevations of 10-80 deg. C, with coagulation verified by histology. Coagulation of precise volumes in the testicle is feasible with MRI-guided focused ultrasound. Variability in peak temperature for given sonication parameters suggests the need for online temperature feedback control.

Authors:
 [1];  [2]; ;  [1]
  1. Department of Medical Biophysics, University of Toronto (Canada)
  2. Imaging Research, Sunnybrook Health Sciences Centre 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 (Canada)
Publication Date:
OSTI Identifier:
21293551
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1113; Journal Issue: 1; Conference: 8. international symposium on therapeutic ultrasound, Minneapolis, MN (United States), 10-13 Sep 2008; Other Information: DOI: 10.1063/1.3131398; (c) 2009 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CONTROL; FEEDBACK; HISTOLOGY; NEOPLASMS; NMR IMAGING; PATIENTS; RABBITS; RADIOTHERAPY; SURGERY; TESTES; TRANSDUCERS; ULTRASONIC WAVES

Citation Formats

Staruch, Robert, Curiel, Laura, Chopra, Rajiv, Hynynen, Kullervo, and Imaging Research, Sunnybrook Health Sciences Centre 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5. Feasibility of MRI-guided Focused Ultrasound as Organ-Sparing Treatment for Testicular Cancer. United States: N. p., 2009. Web. doi:10.1063/1.3131398.
Staruch, Robert, Curiel, Laura, Chopra, Rajiv, Hynynen, Kullervo, & Imaging Research, Sunnybrook Health Sciences Centre 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5. Feasibility of MRI-guided Focused Ultrasound as Organ-Sparing Treatment for Testicular Cancer. United States. doi:10.1063/1.3131398.
Staruch, Robert, Curiel, Laura, Chopra, Rajiv, Hynynen, Kullervo, and Imaging Research, Sunnybrook Health Sciences Centre 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5. Tue . "Feasibility of MRI-guided Focused Ultrasound as Organ-Sparing Treatment for Testicular Cancer". United States. doi:10.1063/1.3131398.
@article{osti_21293551,
title = {Feasibility of MRI-guided Focused Ultrasound as Organ-Sparing Treatment for Testicular Cancer},
author = {Staruch, Robert and Curiel, Laura and Chopra, Rajiv and Hynynen, Kullervo and Imaging Research, Sunnybrook Health Sciences Centre 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5},
abstractNote = {High cure rates for testicular cancer have prompted interest in organ-sparing surgery for patients with bilateral disease or single testis. Focused ultrasound (FUS) ablation could offer a noninvasive approach to organ-sparing surgery. The objective of this study was to determine the feasibility of using MR thermometry to guide organ-sparing focused ultrasound surgery in the testis. The testes of anesthetized rabbits were sonicated in several discrete locations using a single-element focused transducer operating at 2.787MHz. Focal heating was visualized with MR thermometry, using a measured PRF thermal coefficient of -0.0089{+-}0.0003 ppm/ deg. C. Sonications at 3.5-14 acoustic watts applied for 30 seconds produced maximum temperature elevations of 10-80 deg. C, with coagulation verified by histology. Coagulation of precise volumes in the testicle is feasible with MRI-guided focused ultrasound. Variability in peak temperature for given sonication parameters suggests the need for online temperature feedback control.},
doi = {10.1063/1.3131398},
journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1113,
place = {United States},
year = {2009},
month = {4}
}