Histotripsy of the Prostate for the Treatment of BPH: Chronic Results From a Canine Model

Journal Article · Tue Apr 14 00:00:00 EDT 2009 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3131397· OSTI ID:21293550

Hall, Timothy L; Hempel, Chris R; Lake, Alison M; Kieran, Kathy ^[1]; Ives, Kim; Cain, Charles A ^[2]; Fowlkes, J Brian ^[3]; Roberts, William W ^[1]

---

1. University of Michigan Department of Urology, Ann Arbor, MI (United States)
2. University of Michigan Department of Biomedical Engineering, Ann Arbor, MI (United States)
3. University of Michigan Department of Radiology, Ann Arbor, MI (United States)

Histotripsy was evaluated as a non-invasive BPH treatment. The prostates of 21 canine subjects were targeted with one of three histotripsy doses. Prostates were harvested immediately, 7 days, or 28 days after treatment and assessed for changes. Lower treatment doses were found to produced scattered cellular disruption and hemorrhage that was sometimes reversible. Higher doses perforated the urethra and produced cavities in the glandular prostate that healed to leave an enlarged urinary channel.

• OSTI ID: 21293550
• Journal Information: AIP Conference Proceedings, Vol. 1113, Issue 1; Conference: 8. international symposium on therapeutic ultrasound, Minneapolis, MN (United States), 10-13 Sep 2008; Other Information: DOI: 10.1063/1.3131397; (c) 2009 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DOGS
DOSES
HEMORRHAGE
PROSTATE
RADIOTHERAPY
ULTRASONIC WAVES
URINARY TRACT
UROGENITAL SYSTEM DISEASES