Neoadjuvant Treatment Does Not Influence Perioperative Outcome in Rectal Cancer Surgery

Journal Article · Tue Sep 01 04:00:00 EDT 2009 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2008.10.051· OSTI ID:21282003

Ulrich, Alexis ^[1]; Weitz, Juergen ^[1]; Slodczyk, Matthias; Koch, Moritz ^[1]; Jaeger, Dirk ^[2]; Muenter, Marc ^[3]; Buechler, Markus W ^[1]

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1. Department of Surgery, University of Heidelberg, Heidelberg (Germany)
2. Nationales Centrum fuer Tumorerkrankungen, University of Heidelberg, Heidelberg (Germany)
3. Department of Clinical Radiology, Radiooncology and Radiotherapy, University of Heidelberg, Heidelberg (Germany)

Purpose: To identify the risk factors for perioperative morbidity in patients undergoing resection of primary rectal cancer, with a specific focus on the effect of neoadjuvant therapy. Methods and Materials: This exploratory analysis of prospectively collected data included all patients who underwent anterior resection/low anterior resection or abdominoperineal resection for primary rectal cancer between October 2001 and October 2006. The study endpoints were perioperative surgical and medical morbidity. Univariate and multivariate analyses of potential risk factors were performed. Results: A total of 485 patients were included in this study; 425 patients (88%) underwent a sphincter-saving anterior resection/low anterior resection, 47 (10%) abdominoperineal resection, and 13 (2%) multivisceral resection. Neoadjuvant chemoradiotherapy was performed in 100 patients (21%), and 168 (35%) underwent neoadjuvant short-term radiotherapy (5 x 5 Gy). Patient age and operative time were independently associated with perioperative morbidity, and operative time, body mass index >27 kg/m{sup 2} (overweight), and resection type were associated with surgical morbidity. Age and a history of smoking were confirmed as independent prognostic risk factors for medical complications. Neoadjuvant therapy was not associated with a worse outcome. Conclusion: The results of this prospective study have identified several risk factors associated with an adverse perioperative outcome after rectal cancer surgery. In addition, neoadjuvant therapy was not associated with increased perioperative complications.

• OSTI ID: 21282003
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 1 Vol. 75; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
COMBINED THERAPY
DISEASE INCIDENCE
HAZARDS
MULTIVARIATE ANALYSIS
NEOPLASMS
PATIENTS
RADIOTHERAPY
RECTUM
SURGERY