Target Definition by C11-Methionine-PET for the Radiotherapy of Brain Metastases
- Department of Radiation Oncology, Chubu Medical Centre for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo (Japan)
- Department of Neurosurgery, Chubu Medical Centre for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo (Japan)
- Department of Radiology, Kizawa Memorial Hospital, Minokamo (Japan)
- Department of Neurosurgery, Gifu University School of Medicine, Gifu (Japan)
- Department of Radiology, Gifu University School of Medicine, Gifu (Japan)
Purpose: To evaluate the ability of 11C-methionine positron emission tomography (MET-PET) to delineate target volumes for brain metastases and to investigate to what extent tumor growth is presented by magnetic resonance imaging (MRI) and MET-PET. Materials and Methods: Three observers undertook target definition in 19 patients with 95 brain metastases by MRI and MET-PET images. MRI gross target volume (GTV) (GTV-MRI) was defined as the contrast-enhanced area on gadolinium-enhanced T1-weighted MRI. MET-PET GTV (GTV-PET) was defined as the area of an accumulation of MET-PET apparently higher than that of normal tissue on MET-PET images. The size of occupation ratio was determined using the following equation: SOR (%) of MET are within x mm margin outside GTV-MRI = the volume of the GTV-PET within x mm outside the GTV-MRI/the volume of the GTV-PET. Results: For GTV-MRI volumes of {<=}0.5 mL, the sensitivity of tumor detection by MET-PET was 43%. For GTV-MRI volume of >0.5 mL, GTV-PET volumes were larger than GTV-MRI volumes and a significant correlation was found between these variables by linear regression. For all tumor sizes and tumor characteristics, a 2-mm margin outside the GTV-MRI significantly improved the coverage of the GTV-PET. Conclusions: Although there were some limitations in our study associated with spatial resolution, blurring effect, and image registrations with PET images, MET-PET was supposed to have a potential as a promising tool for the precise delineation of target volumes in radiotherapy planning for brain metastases.
- OSTI ID:
- 21276855
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 74; ISSN IOBPD3; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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