Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice

Journal Article · Fri Jan 02 04:00:00 EST 2009 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2008.10.176· OSTI ID:21255818

Ezaki, Hisao; Yoshida, Yuichi; Saji, Yukiko; Takemura, Takayo; Fukushima, Juichi; Matsumoto, Hitoshi; Kamada, Yoshihiro; Wada, Akira; Igura, Takumi ^[1]; Kihara, Shinji; Funahashi, Tohru; Shimomura, Iichiro ^[2]; Tamura, Shinji ^[1]; Kiso, Shinichi ^[1]; Hayashi, Norio ^[1]

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1. Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2, K1, Yamadaoka, Suita, Osaka 565-0871 (Japan)
2. Department of Metabolic Medicine, Osaka University, Graduate School of Medicine, 2-2, B5, Yamadaoka, Suita, Osaka 565-0871 (Japan)

We previously demonstrated that adiponectin has anti-fibrogenic and anti-inflammatory effects in the liver of mouse models of various liver diseases. However, its role in liver regeneration remains unclear. The aim of this study was to determine the role of adiponectin in liver regeneration. We assessed liver regeneration after partial hepatectomy in wild-type (WT) and adiponectin knockout (KO) mice. We analyzed DNA replication and various signaling pathways involved in cell proliferation and metabolism. Adiponectin KO mice exhibited delayed DNA replication and increased lipid accumulation in the regenerating liver. The expression levels of peroxisome proliferator-activated receptor (PPAR) {alpha} and carnitine palmitoyltransferase-1 (CPT-1), a key enzyme in mitochondrial fatty acid oxidation, were decreased in adiponectin KO mice, suggesting possible contribution of altered fat metabolism to these phenomena. Collectively, the present results highlight a new role for adiponectin in the process of liver regeneration.

• OSTI ID: 21255818
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 1 Vol. 378; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BIOLOGICAL REGENERATION
CARNITINE
CELL PROLIFERATION
DNA REPLICATION
HEPATECTOMY
INFLAMMATION
LIVER
METABOLISM
MICE
MITOCHONDRIA
OXIDATION
RECEPTORS
REGENERATION