An apparatus for the preparation of [{sup 15}O]-H{sub 2}O for rapid repetitive PET studies

Journal Article · Thu Jun 10 04:00:00 EDT 1999 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.59093· OSTI ID:21205520

Dahl, J R; Chaly, T C; Matacchieri, R A; Yee, A; Dhawan, V; Horowitz, S; Jespersen, K; Margouleff, D; Eidelberg, D ^[1]

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1. North Shore University Hospital, New York University School of Medicine, Manhassset, New York (United States)

The use of [{sup 15}O]-H{sub 2}O to follow changes in cerebral blood flow using PET has become frequent and widespread, requiring an apparatus easily operated by personnel unfamiliar with the physics and chemistry involved. Oxygen-15 is prepared by the {sup 14}N(d,n){sup 15}O nuclear reaction using a target of UHP nitrogen with 1% UHP hydrogen added, contained in a target chamber similar to that reported for the preparation of [{sup 18}F]-F{sub 2}. Nucleogenic {sup 15}O reacts with hydrogen in the target gas to produce [{sup 15}O]-H{sub 2}O. Some of the N target reacts with hydrogen to produce NH{sub 3}, which must be removed. At the end of bombardment (minimum 6 min.) the target gas is released through a small amount of parenteral water which then flows through approximately 50 mg Dowex 50W-X8 resin (100-200 mesh) to remove the NH{sub 3}. Sufficient 23.4% NaCl solution is added to produce an isotonic solution. The isotonic solution is sterilized by filtration through a 0.22 micron filter into an injection syringe which is sent via pneumatic transport to the PET imaging room. The apparatus, which uses a programmable logic controller and four switches to allow the operator to select standby, refill, collect activity, or deliver dose operations of the production process, provides doses of [{sup 15}O]-H{sub 2}O up to 35 mCi/dose at intervals as frequent as seven minutes with minimal radiation exposure to the operators.

• OSTI ID: 21205520
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 475; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

07 ISOTOPE AND RADIATION SOURCES
43 PARTICLE ACCELERATORS
AMMONIA
BLOOD FLOW
CONTROL SYSTEMS
DEUTERON REACTIONS
FILTRATION
FLUORINE 18
ISOTONIC SOLUTIONS
ISOTOPE PRODUCTION
NITROGEN 14 TARGET
OXYGEN 15
PNEUMATIC TRANSPORT
POSITRON COMPUTED TOMOGRAPHY
RADIATION SOURCES
SODIUM CHLORIDES
TARGET CHAMBERS
WATER