High-temperature chemical and microstructural transformations of an organic-inorganic nanohybrid captopril intercalated Mg-Al layered double hydroxide
- State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Box 98, Beijing 100029 (China)
The thermal evolution of a crystalline organic-inorganic nanohybrid captopril intercalated Mg-Al layered double hydroxide (LDH) [Mg{sub 0.68}Al{sub 0.32}(OH){sub 2}] (C{sub 9}H{sub 13}NO{sub 3}S){sub 0.130}(CO{sub 3}){sub 0.030}.0.53H{sub 2}O obtained by coprecipitation method is studied based upon in situ high-temperature X-ray diffraction, in situ infrared and thermogravimetric analysis coupled with mass spectroscopy analysis. The results reveal that a metastable quasi-interstratified layered nanohybrid involving carbonate-LDH and reoriented less ordered captopril-LDH was firstly observed as captopril-LDH heat-treated between 140 and 230 deg. C. The major decomposition/combustion of interlayer organics occur between 270 and 550 deg. C. A schematic model on chemical and microstructural evolution of this particular drug-inorganic nanohybrid upon heating in air atmosphere is proposed.
- OSTI ID:
- 21199765
- Journal Information:
- Materials Research Bulletin, Vol. 44, Issue 5; Other Information: DOI: 10.1016/j.materresbull.2008.10.016; PII: S0025-5408(08)00378-4; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0025-5408
- Country of Publication:
- United States
- Language:
- English
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