Gated Irradiation With Scanned Particle Beams

Journal Article · Sun Mar 15 04:00:00 EDT 2009 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2008.11.014· OSTI ID:21172693

Bert, Christoph ^[1]; Gemmel, Alexander; Saito, Nami ^[1]; Rietzel, Eike ^[1]

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1. Gesellschaft fuer Schwerionenforschung, Abt. Biophysik, Darmstadt (Germany)

Purpose: To demonstrate mitigation of the interplay effects of scanned particle beams and residual target motion within a gating window by increased overlap of pencil beams. Methods and Materials: Lateral overlap was increased by increasing the pencil beam widths or by decreasing the distance between the pencil beams (scan grid). Longitudinal overlap was increased by reducing the distance between iso-range slices. For scanned carbon ion beams, simulation studies were performed and validated experimentally to determine the required parameters for different residual motion characteristics. The dose distributions were characterized by the maximal local deviations representing local over- and underdosage. Results: For residual lateral motion, the local deviations were <5% for 2, 4, and 7 mm residual motion within the gating window for a 2-mm scan grid and pencil beams of 10, 14, and 18 mm full width at half maximum, respectively. Decreasing the iso-range slice distance from 3 mm to 1 mm effectively mitigated {<=}10 mm water-equivalent range changes. Experimental data reproduced the simulation results. Conclusion: In charged particle therapy with a scanned beam, interplay effects between gated beam delivery and residual target motion can be decreased effectively by increasing the overlap between pencil beams laterally, as well as longitudinally.

• OSTI ID: 21172693
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 4 Vol. 73; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BEAM PROFILES
CARBON IONS
IRRADIATION
PARTICLE BEAMS
RADIATION DOSE DISTRIBUTIONS
RADIOTHERAPY
SIMULATION