A Phase II Trial of Brachytherapy Alone After Lumpectomy for Select Breast Cancer: Tumor Control and Survival Outcomes of RTOG 95-17

Journal Article · Wed Oct 01 04:00:00 EDT 2008 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2007.12.056· OSTI ID:21124473

Winter, Kathryn ^[1]; Kuske, Robert R ^[2]; Bolton, John ^[3]; Rabinovitch, Rachel ^[4]; White, Julia ^[5]; Hanson, William F ^[6]; Wilenzick, Raymond M ^[7]; McCormick, Beryl ^[8]

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1. Department of Statistics, RTOG, Philadelphia, PA (United States)
2. Arizona Oncology Services and Foundation for Cancer Research and Education, Phoenix, AZ (United States)
3. Department of Surgery, Ochsner Clinic, New Orleans, LA (United States)
4. Department of Radiation Oncology, University of Colorado Cancer Center, Denver, CO (United States)
5. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States)
6. Radiologic Physics Center, Houston, TX (United States)
7. Department of Radiation Oncology Physics, Ochsner Foundation Hospital, New Orleans, LA (United States)
8. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY (United States)

Purpose: Radiation Therapy Oncology Group 95-17 is a prospective Phase II cooperative group trial of accelerated partial breast irradiation (APBI) alone using multicatheter brachytherapy after lumpectomy in select early-stage breast cancers. Tumor control and survival outcomes are reported. Methods and Materials: Eligibility criteria included Stage I/II breast carcinoma confirmed to be <3 cm, unifocal, invasive nonlobular histology with zero to three positive axillary nodes without extracapsular extension. APBI treatment was delivered with either low-dose-rate (LDR) (45 Gy in 3.5-5 days) or high-dose-rate (HDR) brachytherapy (34 Gy in 10 twice-daily fractions over 5 days). End points evaluated included in-breast control, regional control, mastectomy-free rate, mastectomy-free survival, disease-free survival, and overall survival. The study was designed to analyze the HDR and LDR groups separately and without comparison. Results: Between 1997 and 2000, 100 patients were accrued and 99 were eligible; 66 treated with HDR brachytherapy and 33 treated with LDR brachytherapy. Eighty-seven patients had T1 lesions and 12 had T2 lesions. Seventy-nine were pathologically N0 and 20 were N1. Median follow-up in the HDR group is 6.14 years with the 5-year estimates of in-breast, regional, and contralateral failure rates of 3%, 5%, and 2%, respectively. The LDR group experienced similar results with a median follow-up of 6.22 years. The 5-year estimates of in-breast, regional, and contralateral failure rates of 6%, 0%, and 6%, respectively. Conclusion: Patients treated with multicatheter partial breast brachytherapy in this trial experienced excellent in-breast control rates and overall outcome that compare with reports from APBI studies with similar extended follow-up.

• OSTI ID: 21124473
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 72; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRACHYTHERAPY
CARCINOMAS
DOSE RATES
FAILURES
HISTOLOGY
IRRADIATION
MAMMARY GLANDS
PATIENTS