Consensus Guidelines for Delineation of Clinical Target Volume for Intensity-Modulated Pelvic Radiotherapy in Postoperative Treatment of Endometrial and Cervical Cancer

Journal Article · Sun Jun 01 04:00:00 EDT 2008 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2007.09.042· OSTI ID:21124273

Small, William ^[1]; Mell, Loren K ^[2]; Anderson, Penny ^[3]; Creutzberg, Carien ^[4]; De Los Santos, Jennifer ^[5]; Gaffney, David ^[6]; Jhingran, Anuja ^[7]; Portelance, Lorraine ^[8]; Schefter, Tracey ^[9]; Iyer, Revathy ^[10]; Varia, Mahesh ^[11]; Winter, Kathryn M.S. ^[12]; Mundt, Arno J ^[13]

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1. Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL (United States)
2. Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States)
3. Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States)
4. Department of Clinical Oncology, Leiden University Medical Center, Leiden (Netherlands)
5. Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL (United States)
6. Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT (United States)
7. Department of Radiation Oncology, M.D. Anderson Cancer Center, Houston, TX (United States)
8. Department of Radiation Oncology, McGill University Health Center, Quebec, ON (Canada)
9. Department of Radiation Oncology, University of Colorado, Aurora, CO (United States)
10. Department of Radiology, M.D. Anderson Cancer Center, Houston, TX (United States)
11. Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC (United States)
12. Statistical Section, Radiation Therapy Oncology Group, Philadelphia, PA (United States)
13. Department of Radiation Oncology, University of California, San Diego, School of Medicine, La Jolla, CA (United States)

Purpose: To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy. Methods and Materials: The Radiation Therapy Oncology Group led an international collaberation of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group, National Cancer Institute of Canada, European Society of Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTV and to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005. Results: The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph node regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, or endometrial cancer with cervical stromal invasion, it is also recommended that the CTV include the presacral lymph node region. Conclusion: This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer.

• OSTI ID: 21124273
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 71; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
COMPUTERIZED TOMOGRAPHY
FEMALE GENITALS
IMAGES
LYMPH NODES
NEOPLASMS
RADIOTHERAPY