Technical note: The calibration of {sup 90}Y-labeled SIR-Spheresusing a nondestructive spectroscopic assay

Journal Article · Tue Apr 15 00:00:00 EDT 2008 · Medical Physics

DOI:https://doi.org/10.1118/1.2889621· OSTI ID:21120636

Selwyn, R; Micka, J; DeWerd, L; Nickles, R; Thomadsen, B ^[1]

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1. Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53706 (United States)

{sup 90}Y-labeled SIR-Spheres are currently used to treat patients with hepatic metastases secondary to colorectal adenocarcinoma. In general, the prescribed activity is based on empirical data collected during clinical trials. The activity of the source vial is labeled by the manufacturer as 3.0 GBq{+-}10% and is not independently verified by the end user. This technical note shows that the results of a nondestructive spectroscopic assay of a SIR-Spheressample was 26% higher than the activity stated by the manufacturer. This difference should not impact the current empirical prescription method but may be problematic for patient-specific dosimetry applications, such as image-based dosimetry.

• OSTI ID: 21120636
• Journal Information: Medical Physics, Vol. 35, Issue 4; Other Information: DOI: 10.1118/1.2889621; (c) 2008 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-2405
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRACHYTHERAPY
CALIBRATION
CARCINOMAS
CLINICAL TRIALS
DOSIMETRY
IMAGES
LIVER
METASTASES
PATIENTS
RADIATION SOURCE IMPLANTS
RADIOPHARMACEUTICALS
SULFUR 26
YTTRIUM 90