Urinary arsenic speciation and its correlation with 8-OHdG in Chinese residents exposed to arsenic through coal burning
Journal Article
·
· Bulletin of Environmental Contamination and Toxicology
- China Medical University, Shenyang (China). Dept. for Occupational & Environmental Health
In contrast to arsenicosis caused by consumption of water contaminated by naturally occurring inorganic arsenic, human exposure to this metalloid through coal burning has been rarely reported. In this study, arsenic speciation and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in urine were determined in the Chinese residents exposed to arsenic through coal burning in Guizhou, China, an epidemic area of chronic arsenic poisoning caused by coal burning. The urinary concentrations of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA) and total arsenic (tAs) of high-arsenic exposed subjects were significantly higher than those of low-arsenic exposed residents. A biomarker of oxidative DNA damage, urinary 8-OHdG level was significantly higher in high-arsenic exposed subjects than that of low exposed. Significant positive correlations were found between 8-OHdG levels and concentrations of iAs, MMA, DMA and tAs, respectively. In addition, a significant negative correlation was observed between 8-OHdG levels and the secondary methylation ratio (DMA/(MMA + DMA)). The results suggest that chronic arsenic exposure through burning coal rich in arsenic is associated with oxidative DNA damages, and that secondary methylation capacity is potentially related to the susceptibility of individuals to oxidative DNA damage induced by arsenic exposure through coal burning in domestic living.
- OSTI ID:
- 21107536
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology, Journal Name: Bulletin of Environmental Contamination and Toxicology Journal Issue: 4 Vol. 81; ISSN 0007-4861; ISSN BECTA6
- Country of Publication:
- United States
- Language:
- English
Similar Records
Urinary 8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenic exposure area
Association of oxidative stress with arsenic methylation in chronic arsenic-exposed children and adults
Oxidative DNA damage and repair in children exposed to low levels of arsenic in utero and during early childhood: Application of salivary and urinary biomarkers
Journal Article
·
Mon Dec 31 23:00:00 EST 2007
· Toxicology and Applied Pharmacology
·
OSTI ID:21077882
Association of oxidative stress with arsenic methylation in chronic arsenic-exposed children and adults
Journal Article
·
Wed Oct 01 00:00:00 EDT 2008
· Toxicology and Applied Pharmacology
·
OSTI ID:21144130
Oxidative DNA damage and repair in children exposed to low levels of arsenic in utero and during early childhood: Application of salivary and urinary biomarkers
Journal Article
·
Sat Dec 14 23:00:00 EST 2013
· Toxicology and Applied Pharmacology
·
OSTI ID:22285538