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Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model

Journal Article · · Cardiovascular and Interventional Radiology
;  [1]; ;  [2];  [1];  [2];  [3];  [1];  [2]; ;  [1];
  1. Zhongda Hospital of Southeast University, Department of Radiology (China)
  2. Zhongda Hospital of Southeast University, Department of Cardiology (China)
  3. Zhongda Hospital of Southeast University, Department of Anaesthesiology (China)
+ Show Author Affiliations

Purpose. To compare a necrosis-avid contrast agent (NACA) bis-Gd-DTPA-pamoic acid derivative (ECIII-60) after intracoronary delivery with an extracellular agent Gd-DTPA after intravenous injection on magnetic resonance imaging (MRI) in a swine model of acute reperfused myocardial infarction (MI). Methods. Eight pigs underwent 90 min of transcatheter coronary balloon occlusion and 60 min of reperfusion. After intravenous injection of Gd-DTPA at a dose of 0.2 mmol/kg, all pigs were scanned with T1-weighted MRI until the delayed enhancement of MI disappeared. Then they were intracoronarily infused with ECIII-60 at 0.0025 mmol/kg and imaged for 5 hr. Signal intensity, infarct-over-normal contrast ratio and relative infarct size were quantified, compared, and correlated with the results of postmortem MRI and triphenyltetrazolium chloride (TTC) histochemical staining. Results. A contrast ratio over 3.0 was induced by both Gd-DTPA and ECIII-60. However, while the delayed enhancement with Gd-DTPA virtually vanished in 1 hr, ECIII-60 at an 80x smaller dose depicted the MI accurately over 5 hr as proven by ex vivo MRI and TTC staining. Conclusion. Both Gd-DTPA and ECIII-60 strongly enhanced acute MI. Comparing with fading contrast in a narrow time window with intravenous Gd-DTPA, intracoronary ECIII-60 persistently demarcated the acute MI, indicating a potential method for postprocedural assessment of myocardial viability after coronary interventions.

OSTI ID:
21091008
Journal Information:
Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 2 Vol. 30; ISSN 0174-1551; ISSN CAIRDG
Country of Publication:
United States
Language:
English

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Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CHLORIDES
CONTRAST MEDIA
CORONARIES
GADOLINIUM COMPOUNDS
INTRAVENOUS INJECTION
MYOCARDIAL INFARCTION
NECROSIS
NMR IMAGING
SWINE