Human Thrombin Injection for the Percutaneous Treatment of Iatrogenic Pseudoaneurysms

Journal Article · Fri Mar 15 04:00:00 EST 2002 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-001-0081-Z· OSTI ID:21083454

Elford, Julian ^[1]; Burrell, Christopher ^[2]; Freeman, Simon; Roobottom, Carl ^[1]

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1. Department of Radiology, DerrifordHospital, Plymouth PL6 8DH (United Kingdom)
2. Department of Cardiology, DerrifordHospital, Plymouth PL6 8DH (United Kingdom)

Purpose: Thrombin injection is becoming well established for the percutaneous management of iatrogenic pseudoaneurysms. All the published series to date use bovine thrombin,and there have been reports of adverse immunologic effects following its use. Our study aimed to assess the efficacy of human thrombin injection for pseudoaneurysm occlusion. Methods:Fourteen patients with iatrogenic pseudoaneurysms underwent a color Doppler ultrasound examination to assess their suitability for percutaneous human thrombin injection. Human thrombin 1000 IU was then injected into the pseudoaneurysm sac under sterile conditions and with ultrasound guidance. A further color Doppler ultrasound examination was performed 24 hr later to confirm occlusion. Results: All 14 pseudoaneurysms were successfully occluded by human thrombin injection. In two cases a second injection of thrombin was required,but there were no other complications, and all pseudoaneurysms remained occluded at 24 hr. Conclusion: Ultrasound-guided human thrombin injection is simple to perform, effective and safe. We recommend that human thrombin becomes the agent of choice for percutaneous injection into iatrogenic pseudoaneurysms.

• OSTI ID: 21083454
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 2 Vol. 25; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BIOMEDICAL RADIOGRAPHY
CATTLE
COLOR MODEL
INJECTION
PATIENTS
THROMBIN
VASCULAR DISEASES