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Title: Tandem-ESQ for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT)

Abstract

A folded tandem, with 1.25 MV terminal voltage, combined with an ElectroStatic Quadrupole (ESQ) chain is being proposed as a machine for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT). The machine is shown to be capable of accelerating a 30 mA proton beam to 2.5 MeV. These are the specifications needed to produce sufficiently intense and clean epithermal neutron beams, based on the on the 7Li(p,n)7Be reaction, to perform BNCT treatment for deep seated tumors in less than an hour.

Authors:
 [1];  [2];  [2]; ;  [3]; ; ; ;  [4];  [2]; ;  [5]
  1. Departamento de Fisica, Comision Nacional de Energia Atomica (Argentina)
  2. (Argentina)
  3. Ernest Orlando Lawrence Berkeley National Laboratory, Univ. of California, Berkeley, CA (United States)
  4. Departamento de Fisica, Comision Nacional de Energia Atomica, (Argentina)
  5. Escuela de Ciencia y Tecnologia, Universidad de Gral San Martin (Argentina)
Publication Date:
OSTI Identifier:
21054819
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 884; Journal Issue: 1; Conference: 6. Latin American symposium on nuclear physics and applications, Iguazu (Argentina), 3-7 Oct 2005; Other Information: DOI: 10.1063/1.2710584; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; BEAM PRODUCTION; BERYLLIUM 7; ELECTROSTATIC ACCELERATORS; EPITHERMAL NEUTRONS; LITHIUM 7; MEV RANGE; MILLI AMP BEAM CURRENTS; NEOPLASMS; NEUTRON BEAMS; NEUTRON CAPTURE THERAPY; PROTON BEAMS; PROTON REACTIONS; PROTON-NUCLEON INTERACTIONS; QUADRUPOLES; SPECIFICATIONS

Citation Formats

Kreiner, A. J., Escuela de Ciencia y Tecnologia, Universidad de Gral San Martin, CONICET,, Kwan, J. W., Henestroza, E., Burlon, A. A., Di Paolo, H., Minsky, D., Debray, M., Escuela de Ciencia y Tecnologia, Universidad de Gral San Martin, Valda, A., and Somacal, H. R.. Tandem-ESQ for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT). United States: N. p., 2007. Web. doi:10.1063/1.2710584.
Kreiner, A. J., Escuela de Ciencia y Tecnologia, Universidad de Gral San Martin, CONICET,, Kwan, J. W., Henestroza, E., Burlon, A. A., Di Paolo, H., Minsky, D., Debray, M., Escuela de Ciencia y Tecnologia, Universidad de Gral San Martin, Valda, A., & Somacal, H. R.. Tandem-ESQ for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT). United States. doi:10.1063/1.2710584.
Kreiner, A. J., Escuela de Ciencia y Tecnologia, Universidad de Gral San Martin, CONICET,, Kwan, J. W., Henestroza, E., Burlon, A. A., Di Paolo, H., Minsky, D., Debray, M., Escuela de Ciencia y Tecnologia, Universidad de Gral San Martin, Valda, A., and Somacal, H. R.. Mon . "Tandem-ESQ for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT)". United States. doi:10.1063/1.2710584.
@article{osti_21054819,
title = {Tandem-ESQ for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT)},
author = {Kreiner, A. J. and Escuela de Ciencia y Tecnologia, Universidad de Gral San Martin and CONICET, and Kwan, J. W. and Henestroza, E. and Burlon, A. A. and Di Paolo, H. and Minsky, D. and Debray, M. and Escuela de Ciencia y Tecnologia, Universidad de Gral San Martin and Valda, A. and Somacal, H. R.},
abstractNote = {A folded tandem, with 1.25 MV terminal voltage, combined with an ElectroStatic Quadrupole (ESQ) chain is being proposed as a machine for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT). The machine is shown to be capable of accelerating a 30 mA proton beam to 2.5 MeV. These are the specifications needed to produce sufficiently intense and clean epithermal neutron beams, based on the on the 7Li(p,n)7Be reaction, to perform BNCT treatment for deep seated tumors in less than an hour.},
doi = {10.1063/1.2710584},
journal = {AIP Conference Proceedings},
number = 1,
volume = 884,
place = {United States},
year = {Mon Feb 12 00:00:00 EST 2007},
month = {Mon Feb 12 00:00:00 EST 2007}
}
  • In the frame of the construction of a Tandem Electrostatic Quadrupole Accelerator facility devoted to the Accelerator-Based Boron Neutron Capture Therapy, a Beam Shaping Assembly has been characterized by means of Monte-Carlo simulations and measurements. The neutrons were generated via the {sup 7}Li(p, n){sup 7}Be reaction by irradiating a thick LiF target with a 2.3 MeV proton beam delivered by the TANDAR accelerator at CNEA. The emerging neutron flux was measured by means of activation foils while the beam quality and directionality was evaluated by means of Monte Carlo simulations. The parameters show compliance with those suggested by IAEA. Finally,more » an improvement adding a beam collimator has been evaluated.« less
  • There is a generalized perception that the availability of suitable particle accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of Boron Neutron Capture Therapy (BNCT). Progress on an ongoing project to develop a Tandem-ElectroStatic-Quadrupole (TESQ) accelerator for Accelerator-Based (AB)-BNCT is described here. The project goal is a machine capable of delivering 30 mA of 2.5 MeV protons to be used in conjunction with a neutron production target based on the {sup 7}Li(p,n){sup 7}Be reaction slightly beyond its resonance at 2.25 MeV. A folded tandem, with 1.25 MV terminal voltage, combined with an ESQ chain ismore » being designed and constructed. A 30 mA proton beam of 2.5 MeV are the specifications needed to produce sufficiently intense and clean epithermal neutron beams, based on the {sup 7}Li(p,n){sup 7}Be reaction, to perform BNCT treatment for deep-seated tumors in less than an hour. The first design and construction of an ESQ module is discussed and its electrostatic fields are investigated theoretically and experimentally. Also new beam transport calculations through the accelerator are presented.« less
  • Boron neutron capture therapy (BNCT) was proposed for untreatable colorectal liver metastases. Employing an experimental model of liver metastases in rats, we recently demonstrated that BNCT mediated by boronophenylalanine (BPA-BNCT) at 13 Gy prescribed to tumor is therapeutically useful at 3-week follow-up. The aim of the present study was to evaluate dose–response at 5-week follow-up, based on retrospective dose assessment in individual rats. BDIX rats were inoculated with syngeneic colon cancer cells DHD/K12/TRb. Tumor-bearing animals were divided into three groups: BPA-BNCT (n = 19), Beam only (n = 8) and Sham (n = 7) (matched manipulation, no treatment). For eachmore » rat, neutron flux was measured in situ and boron content was measured in a pre-irradiation blood sample for retrospective individual dose assessment. For statistical analysis (ANOVA), individual data for the BPA-BNCT group were pooled according to absorbed tumor dose, BPA-BNCT I: 4.5–8.9 Gy and BPA-BNCT II: 9.2–16 Gy. At 5 weeks post-irradiation, the tumor surface area post-treatment/pre-treatment ratio was 12.2 +/- 6.6 for Sham, 7.8 +/- 4.1 for Beam only, 4.4 +/- 5.6 for BPA-BNCT I and 0.45 +/- 0.20 for BPA-BNCT II; tumor nodule weight was 750 +/- 480 mg for Sham, 960 +/- 620 mg for Beam only, 380 +/- 720 mg for BPA-BNCT I and 7.3 +/- 5.9 mg for BPA-BNCT II. The BPA-BNCT II group exhibited statistically significant tumor control with no contributory liver toxicity. Potential threshold doses for tumor response and significant tumor control were established at 6.1 and 9.2 Gy, respectively.« less
  • A source for boron neutron capture therapy (BNCT) comprises a body of photoneutron emitter that includes heavy water and is closely surrounded in heat-imparting relationship by target material; one or more electron linear accelerators for supplying electron radiation having energy of substantially 2 to 10 MeV and for impinging such radiation on the target material, whereby photoneutrons are produced and heat is absorbed from the target material by the body of photoneutron emitter. The heavy water is circulated through a cooling arrangement to remove heat. A tank, desirably cylindrical or spherical, contains the heavy water, and a desired number ofmore » the electron accelerators circumferentially surround the tank and the target material as preferably made up of thin plates of metallic tungsten. Neutrons generated within the tank are passed through a surrounding region containing neutron filtering and moderating materials and through neutron delimiting structure to produce a beam or beams of epithermal neutrons normally having a minimum flux intensity level of 1.0{times}10{sup 9} neutrons per square centimeter per second. Such beam or beams of epithermal neutrons are passed through gamma ray attenuating material to provide the required epithermal neutrons for BNCT use. 3 figs.« less
  • A source for boron neutron capture therapy (BNCT) comprises a body of photoneutron emitter that includes heavy water and is closely surrounded in heat-imparting relationship by target material; one or more electron linear accelerators for supplying electron radiation having energy of substantially 2 to 10 MeV and for impinging such radiation on the target material, whereby photoneutrons are produced and heat is absorbed from the target material by the body of photoneutron emitter. The heavy water is circulated through a cooling arrangement to remove heat. A tank, desirably cylindrical or spherical, contains the heavy water, and a desired number ofmore » the electron accelerators circumferentially surround the tank and the target material as preferably made up of thin plates of metallic tungsten. Neutrons generated within the tank are passed through a surrounding region containing neutron filtering and moderating materials and through neutron delimiting structure to produce a beam or beams of epithermal neutrons normally having a minimum flux intensity level of 1.0.times.10.sup.9 neutrons per square centimeter per second. Such beam or beams of epithermal neutrons are passed through gamma ray attenuating material to provide the required epithermal neutrons for BNCT use.« less