Trichloroethylene: Reevaluation of cancer risks using physiological models
- Tri-Service Toxicology, WPAFB, OH (United States)
Trichloroethylene (TCE) is a widespread groundwater contaminant that is regulated as a carcinogen. Toxicology information used to establish the US EPA drinking water standard (Maximum Contaminant Level) for TCE was based on information collected from 1970 to 1985. Today, significant progress has been made in understanding the mode of action that TCE and its metabolites exert on rodent and human tissues and organs. In addition, physiologically based pharmacokinetic (PB-PK) models are used to account for animal and human differences in metabolism and kinetics of TCE and its metabolites. TCE PB-PK models have been used for low dose extrapolation of cancer risks. This paper presents theoretical cancer risks for TCE using PBPK modeling techniques and compares the outcome with EPA derived cancer risks for TCE.
- OSTI ID:
- 210489
- Report Number(s):
- CONF-9509139--
- Country of Publication:
- United States
- Language:
- English
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