Relationship between circadian oscillations of Rev-erb{alpha} expression and intracellular levels of its ligand, heme
- Nuclear Receptor Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, LA 70808 (United States)
The nuclear hormone receptors, REV-ERB{alpha} [NR1D1] and REV-ERB{beta} [NR1D1], were recently demonstrated to be receptors for the porphyrin, heme. Heme regulates the ability of these receptors to repress transcription of their target genes via modulation of the affinity of the receptor's ligand binding domain for the corepressor, NCoR. The REV-ERBs function as critical components of the mammalian clock and their expression oscillates in a circadian manner. Here, we show that in NIH3T3 cells intracellular heme levels also oscillate in a circadian fashion. These data are the first to show the temporal relationship of intracellular heme levels to the expression of its receptor, Rev-erb{alpha}, and suggest that the rapid oscillations in heme levels may an important component regulating REV-ERB transcriptional activity.
- OSTI ID:
- 21043715
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 368, Issue 4; Other Information: DOI: 10.1016/j.bbrc.2008.02.031; PII: S0006-291X(08)00263-5; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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