Hard X-ray Microscopic Imaging Of Human Breast Tissues

Journal Article · Fri Jan 19 04:00:00 EST 2007 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.2436462· OSTI ID:21043412

Park, Sung H; Kim, Hong T; Kim, Jong K ^[1]; Jheon, Sang H ^[2]; Youn, Hwa S ^[3]

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1. College of Medicine, Catholic University of Daegu, 3056-6 Daemyung-Dong, Nam-Gu, Daegu 705-718 (Korea, Republic of)
2. College of Medicine, Seoul National University, 27 Youngun-Dong, Jongro-Gu, Seoul 110-799 (Korea, Republic of)
3. Pohang Accelerator Laboratory, Pohang University of Science and Technology, 31 San, Hyoja-dong, Pohang, KyungBuk 790-784 (Korea, Republic of)

X-ray microscopy with synchrotron radiation will be a useful tool for innovation of x-ray imaging in clinical and laboratory settings. It helps us observe detailed internal structure of material samples non-invasively in air. And, it also has the potential to solve some tough problems of conventional breast imaging if it could evaluate various conditions of breast tissue effectively. A new hard x-ray microscope with a spatial resolution better than 100 nm was installed at Pohang Light Source, a third generation synchrotron radiation facility in Pohang, Korea. The x-ray energy was set at 6.95 keV, and the x-ray beam was monochromatized by W/B4C monochromator. Condenser and objective zone plates were used as x-ray lenses. Zernike phase plate next to condenser zone plate was introduced for improved contrast imaging. The image of a sample was magnified 30 times by objective zone plate and 20 times by microscope objective, respectively. After additional 10 times digital magnification, the total magnifying power was up to 6000 times in the end. Phase contrast synchrotron images of 10-{mu}m-thick female breast tissue of the normal, fibroadenoma, fibrocystic change and carcinoma cases were obtained. By phase contrast imaging, hard x-rays enable us to observe many structures of breast tissue without sample preparations such as staining or fixation.

• OSTI ID: 21043412
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 879; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
HARD X RADIATION
IMAGES
KEV RANGE
MAMMARY GLANDS
MICROSCOPY
PLATES
POHANG LIGHT SOURCE
SPATIAL RESOLUTION
SYNCHROTRON RADIATION
X-RAY DIFFRACTION
ZONES