A continuous GRASP to determine the relationship between drugs and adverse reactions

Journal Article · Mon Nov 05 00:00:00 EST 2007 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.2817334· OSTI ID:21039230

Hirsch, Michael J ^[1]; Meneses, Claudio N; Pardalos, Panos M; Ragle, Michelle ^[2]; Resende, Mauricio G. C. ^[3]

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1. Raytheon, Inc., Network Centric Systems, P.O. Box 12248, St. Petersburg, FL, 33733 (United States)
2. Department of Industrial and Systems Engineering, University of Florida, 303 Weil Hall, Gainesville, FL, 32611 (United States)
3. Algorithms and Optimization Research Department, AT and T Labs Research, 180 Park Avenue, Room C241, Florham Park, NJ 07932 (United States)

Adverse drag reactions (ADRs) are estimated to be one of the leading causes of death. Many national and international agencies have set up databases of ADR reports for the express purpose of determining the relationship between drugs and adverse reactions that they cause. We formulate the drug-reaction relationship problem as a continuous optimization problem and utilize C-GRASP, a new continuous global optimization heuristic, to approximately determine the relationship between drugs and adverse reactions. Our approach is compared against others in the literature and is shown to find better solutions.

• OSTI ID: 21039230
• Journal Information: AIP Conference Proceedings, Vol. 953, Issue 1; Conference: Conference on data mining, systems analysis and optimization in biomedicine, Gainesville, FL (United States), 28-30 Mar 2007; Other Information: DOI: 10.1063/1.2817334; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
COMPARATIVE EVALUATIONS
DRUGS
MEDICINE
OPTIMIZATION
PATIENTS