Results of Bladder-Conserving Treatment, Consisting of Brachytherapy Combined With Limited Surgery and External Beam Radiotherapy, for Patients With Solitary T1-T3 Bladder Tumors Less Than 5 cm in Diameter

Journal Article · Mon Oct 01 04:00:00 EDT 2007 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2007.03.014· OSTI ID:21036247

Blank, Leo; Koedooder, Kees; Os, Rob van; Kar, Marlou van de ^[1]; Koning, Caro ^[1]

---

1. Department of Radiotherapy, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands)

Purpose: To evaluate the long-term, local relapse-free, distant metastasis-free, and overall survival rates in patients with a solitary bladder tumor <5 cm in diameter who were treated with external beam radiotherapy, limited surgery, and brachytherapy. Methods and Materials: The results of 122 patients after bladder-saving treatment were analyzed. After EBRT, the patients underwent cystotomy, and catheters were implanted. Of the 122 patients, 99 were treated with a continuous low-dose-rate technique and 23 patients with a pulsed-dose-rate technique. The median follow-up period was 5 years. Results: The 5-year local and distant relapse-free survival rate was 76% and 83%, respectively. The 5 and 10-year relapse-free survival rate was 69% and 66%, respectively. For overall survival, the corresponding rates were 73% and 49%. Toxicity was low. No differences were found between the continuous low-dose-rate and pulsed-dose-rate groups. Conclusion: The results of our study have shown that external beam radiotherapy followed by brachytherapy as a bladder-saving treatment for a selected group of patients with bladder cancer yields excellent local tumor control and low toxicity.

• OSTI ID: 21036247
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 69; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BEAMS
BLADDER
BRACHYTHERAPY
CARCINOMAS
DOSE RATES
METASTASES
PATIENTS
SURGERY
TOXICITY