Impact of External Beam Adjuvant Radiotherapy on Health-Related Quality of Life for Long-Term Survivors of Endometrial Adenocarcinoma: A Population-Based Study

Journal Article · Sat Sep 01 04:00:00 EDT 2007 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2007.02.040· OSTI ID:21036207

Poll-Franse, Lonneke V. van de, ^[1]; Mols, Floortje ^[1]; Essink-Bot, Marie-Louise ^[2]; Haartsen, Joke E ^[3]; Lybeert, Marnix L.M.; Berg, Hetty A. van den ^[4]; Coebergh, Jan Willem W ^[1]

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1. Comprehensive Cancer Centre South (IKZ)/Eindhoven Cancer Registry, Eindhoven (Netherlands)
2. Department of Public Health, Erasmus Medical Center/University Medical Centre Rotterdam, Rotterdam (Netherlands)
3. Department of Gynaecology, Elkerliek Hospital, Helmond (Netherlands)
4. Department of Radiotherapy, Catharina Hospital, Eindhoven (Netherlands)

Purpose: To compare the health-related quality of life (HRQOL) among 5-10-year survivors of Stage I-II endometrial (adeno-)carcinoma (EC) treated with surgery alone or surgery with external beam adjuvant radiotherapy (EBRT) and an age-matched norm population. Methods and Materials: A population-based, cross-sectional survey was conducted by the Eindhoven Cancer Registry. All patients were included who had been diagnosed with EC between 1994 and 1998 (n = 462). Information from the questionnaires returned was linked to data from the Eindhoven Cancer Registry on patient, tumor, and treatment characteristics. Results: Responses were received from 75% of the patients. The analyses were restricted to women with Stage I-II disease at diagnosis, treated with either surgery alone or surgery with adjuvant EBRT, and without recurrent disease or new primary malignancies (n = 264). The patients who had received adjuvant EBRT (n = 80) had had a significantly higher tumor stage and grade at diagnosis (p < 0.0001) and a longer mean time since diagnosis (p = 0.04). Age, number of comorbid diseases, current marital status, nulliparity, education, and occupation were similar for both treatment groups. On multivariate analyses, adjuvant EBRT was independently and negatively associated with the vitality and physical and social well-being scale scores. The HRQOL scores of both treatment groups, however, were similar to those of an age-matched norm population. Conclusion: In general, the HRQOL of EC survivors is good. EC survivors treated with surgery alone had a better HRQOL than women treated with surgery and adjuvant EBRT, although for both groups, the HRQOL was in the range of the norm population.

• OSTI ID: 21036207
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 1 Vol. 69; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BEAMS
CARCINOMAS
DIAGNOSIS
MULTIVARIATE ANALYSIS
PATIENTS
RADIOTHERAPY
SURGERY
WOMEN