A computational implementation and comparison of several intensity modulated proton therapy treatment planning algorithms

Journal Article · Sat Mar 15 04:00:00 EDT 2008 · Medical Physics

DOI:https://doi.org/10.1118/1.2836954· OSTI ID:21036175

Li, Haisen S; Romeijn, H Edwin; Fox, Christopher; Palta, Jatinder R; Dempsey, James F ^[1]

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1. Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida 32610-0385 (United States)

The authors present a comparative study of intensity modulated proton therapy (IMPT) treatment planning employing algorithms of three-dimensional (3D) modulation, and 2.5-dimensional (2.5D) modulation, and intensity modulated distal edge tracking (DET) [A. Lomax, Phys. Med. Biol. 44, 185-205 (1999)] applied to the treatment of head-and-neck cancer radiotherapy. These three approaches were also compared with 6 MV photon intensity modulated radiation therapy (IMRT). All algorithms were implemented in the University of Florida Optimized Radiation Therapy system using a finite sized pencil beam dose model and a convex fluence map optimization model. The 3D IMPT and the DET algorithms showed considerable advantages over the photon IMRT in terms of dose conformity and sparing of organs at risk when the beam number was not constrained. The 2.5D algorithm did not show an advantage over the photon IMRT except in the dose reduction to the distant healthy tissues, which is inherent in proton beam delivery. The influences of proton beam number and pencil beam size on the IMPT plan quality were also studied. Out of 24 cases studied, three cases could be adequately planned with one beam and 12 cases could be adequately planned with two beams, but the dose uniformity was often marginally acceptable. Adding one or two more beams in each case dramatically improved the dose uniformity. The finite pencil beam size had more influence on the plan quality of the 2.5D and DET algorithms than that of the 3D IMPT. To obtain a satisfactory plan quality, a 0.5 cm pencil beam size was required for the 3D IMPT and a 0.3 cm size was required for the 2.5D and the DET algorithms. Delivery of the IMPT plans produced in this study would require a proton beam spot scanning technique that has yet to be developed clinically.

• OSTI ID: 21036175
• Journal Information: Medical Physics, Journal Name: Medical Physics Journal Issue: 3 Vol. 35; ISSN 0094-2405; ISSN MPHYA6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ALGORITHMS
DOSIMETRY
MODULATION
NEOPLASMS
OPTIMIZATION
ORGANS
PLANNING
PROTON BEAMS
RADIATION DOSES
RADIOTHERAPY