Netrin-1 induces proliferation of Schwann cells through Unc5b receptor

Journal Article · Sat Nov 03 04:00:00 EDT 2007 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2007.08.143· OSTI ID:21032956

Lee, Hyun Kyoung; Seo, In Ae ^[1]; Seo, Eunhui ^[2]; Seo, Su-Yeong ^[3]; Lee, Hye Jeong ^[2]

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1. Department of Physiology, College of Medicine, Dong-A University, 3-1, Dongdaesin-Dong, Seo-Gu, Busan 602-714 (Korea, Republic of)
2. Department of Pharmacology, College of Medicine, Dong-A University, 3-1, Dongdaesin-Dong, Seo-Gu, Busan 602-714 (Korea, Republic of)
3. Department of Microbiology, Medical Science Research Institute, College of Medicine, Dong-A University, 3-1, Dongdaesin-Dong, Seo-Gu, Busan 602-714 (Korea, Republic of)

Netrin and its receptors, DCC (Deleted in Colorectal Cancer) and Unc5, are proposed to be involved in the axon guidance and neuroglial migration during development. However, accumulating evidence implies that they may also participate in the cell survival and apoptosis. Here, we show that netrin-1 induces proliferation of Schwann cells. Unc5b is the sole receptor expressed in RT4 schwannoma cells and adult primary Schwann cells, and netrin-1 and Unc5b are found to be expressed in the injured sciatic nerve. It was also found that the netrin-1-induced Schwann cell proliferation was blocked by the specific inhibition of Unc5b expression with RNAi. These data suggest that netrin-1 could be an endogenous trophic factor for Schwann cells in the injured peripheral nerves.

• OSTI ID: 21032956
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 4 Vol. 362; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
APOPTOSIS
BROMIDES
CATTLE
CELL PROLIFERATION
ELECTROPHORESIS
GANGLIONS
GELS
LEAD SULFIDES
LEUKEMIA
NERVE CELLS
PHOSPHATES
RECEPTORS
SCIATIC NERVE
SULFATES