Choosing the optimal fit function: Comparison of the Akaike information criterion and the F-test
- Klinik fuer Nuklearmedizin, Universitaet Ulm, D-89070 Ulm (Germany)
In many circumstances of data fitting one has to choose the optimal fitting function or model among several alternatives. Criteria or tests on which this decision is based are necessary and have to be well selected. In this preliminary analysis the application of the corrected Akaike information criterion is demonstrated considering the example of determining pharmacokinetic parameters for the blood serum time activity curves of {sup 111}In-labeled anti-CD66 antibody. Another model selection criterion, the F-test, is used for comparison. For the investigated data the corrected Akaike information criterion has proved to be an effective and efficient approach, applicable to nested and non-nested models.
- OSTI ID:
- 21032840
- Journal Information:
- Medical Physics, Journal Name: Medical Physics Journal Issue: 11 Vol. 34; ISSN 0094-2405; ISSN MPHYA6
- Country of Publication:
- United States
- Language:
- English
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