Plasma and Cavitation Dynamics during Pulsed Laser Microsurgery in vivo

Journal Article · Fri Oct 12 00:00:00 EDT 2007 · Physical Review Letters

DOI:https://doi.org/10.1103/PHYSREVLETT.99.158104· OSTI ID:21024273

Hutson, M Shane; Xiaoyan, Ma ^[1]

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1. Department of Physics and Astronomy, Vanderbilt University, VU Station B no. 351807, Nashville, Tennessee 37235-1807 (United States)

We compare the plasma and cavitation dynamics underlying pulsed laser microsurgery in water and in fruit fly embryos (in vivo)--specifically for nanosecond pulses at 355 and 532 nm. We find two key differences. First, the plasma-formation thresholds are lower in vivo --especially at 355 nm--due to the presence of endogenous chromophores that serve as additional sources for plasma seed electrons. Second, the biological matrix constrains the growth of laser-induced cavitation bubbles. Both effects reduce the disrupted region in vivo when compared to extrapolations from measurements in water.

• OSTI ID: 21024273
• Journal Information: Physical Review Letters, Vol. 99, Issue 15; Other Information: DOI: 10.1103/PhysRevLett.99.158104; (c) 2007 The American Physical Society; Country of input: International Atomic Energy Agency (IAEA); ISSN 0031-9007
• Country of Publication: United States
• Language: English

Related Subjects

71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
36 MATERIALS SCIENCE
60 APPLIED LIFE SCIENCES
BUBBLES
CAVITATION
ELECTRONS
EMBRYOS
EXTRAPOLATION
FRUIT FLIES
IN VIVO
LASERS
PLASMA
PLASMA SEEDING
WATER