Characterization of sodium phenytoin co-gelled with titania for a controlled drug-release system
- Universidad Autonoma Metropolitana-Iztapalapa, Department of Chemistry, P.O. Box 55-534, Mexico 09340 D. F. (Mexico)
- Cinvestav-I.P.N. Unidad Merida. Applied Physics Department, P.O. Box. 73, Cordemex, 97310, Merida, Yucatan (Mexico)
- Instituto Nacional de Neurologia y Neurocirugia 'MVS', Av. Insurgentes Sur 3877. Col. La Fama. P.O. Box 14269 Mexico D. F. (Mexico)
- Physics Institute, UNAM, Circuito de la Investigacion, s/n, Mex. D.F. (Mexico)
Sodium phenytoin, C{sub 15}H{sub 11}N{sub 2}NaO{sub 2}, in several concentrations was co-gelled with titania (TiO{sub 2}), by a sol-gel process. This technique is a promising method to encapsulate several drugs, in this case, phenytoin is an anticonvulsant used to control epileptic seizures. Samples were prepared by adding different concentrations (X = 50, 100, 200 and 250 mg per 20 g of titania matrix) of sodium phenytoin (Ph) to a solution of titanium n-butoxide. The resulting titania-Ph-X materials were characterized by transmission electron microscopy (TEM), Fourier transformed infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and Brunauer-Emmet-Teller (BET) surface areas. The porous nanomaterials showed a wide range of particle size, from 10 to 210 nm, with a mean pore diameter of 5 nm. X-ray diffraction showed an amorphous structure of the prepared samples.
- OSTI ID:
- 21003588
- Journal Information:
- Materials Characterization, Vol. 58, Issue 8-9; Conference: 14. International materials research congress: Symposium 7, Cancun (Mexico), 21-25 Aug 2005; Other Information: DOI: 10.1016/j.matchar.2006.11.006; PII: S1044-5803(06)00327-5; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 1044-5803
- Country of Publication:
- United States
- Language:
- English
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