Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

Journal Article · Sun Jul 01 00:00:00 EDT 2007 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2007.02.015· OSTI ID:20976979

Calabrese, Edward J ^[1]; Bachmann, Kenneth A ^[2]; Bailer, A John ^[3]; Bolger, P Michael ^[4]; Borak, Jonathan ^[5]; Cai, Lu ^[6]; Cedergreen, Nina ^[7]; Cherian, M George ^[8]; Chiueh, Chuang C ^[9]; Clarkson, Thomas W ^[10]; Cook, Ralph R ^[11]; Diamond, David M ^[12]; Doolittle, David J ^[13]; Dorato, Michael A ^[14]; Duke, Stephen O ^[15]; Feinendegen, Ludwig ^[16]; Gardner, Donald E ^[17]; Hart, Ronald W ^[18]; Hastings, Kenneth L ^[4]; Hayes, A Wallace ^[19] ; Hoffmann, George R ^[20]; Ives, John A ^[21]; Jaworowski, Zbigniew ^[22]; Johnson, Thomas E ^[23]; Jonas, Wayne B ^[21]; Kaminski, Norbert E ^[24]

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1. School of Public Health, Morrill I, N344, Univ. of Massachusetts, Amherst, MA 01003 (United States)
2. Univ. of Toledo, OH 43606 (United States)
3. Miami Univ., FL 33124 (United States)
4. US Food and Drug Administration, MD 20857 (United States)
5. Yale Univ., CT 06520 (United States)
6. Univ. of Louisville School of Medicine, KY 40292 (United States)
7. The Royal Veterinary and Agricultural Univ. (KVL) (Denmark)
8. Univ. of Western Ontario (Canada)
9. Taipei Medical Univ., Taipei, Taiwan (China)
10. Univ. of Rochester, NY 14627 (United States)
11. RRC Consulting, LLC, TX 78727 (United States)
12. Univ. of South Florida, FL 33620 (United States)
13. RJR Tobacco Company, NC 27101 (United States)
14. Eli Lilly and Company, IN 46285 (United States)
15. ARS, USDA, MD 20857 (United States)
16. Heinrich-Heine-Univ. Duesseldorf (Germany)
17. Inhalation Toxicology Associates, DC 20006 (United States)
18. NCTR, US Food and Drug Administration (Retired), MD 20857 (United States)
19. Harvard Univ., MA 02114 (United States)
20. College of the Holy Cross, MA 01610 (United States)
21. Samueli Institute for Information Biology, VA 22314 (United States)
22. Central Lab for Radiological Protection, Warszawa (Poland)
23. Univ. of Colorado, CO 80309 (United States)
24. Michigan State Univ., MI 48824 (United States); and others

Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.

• OSTI ID: 20976979
• Journal Information: Toxicology and Applied Pharmacology, Vol. 222, Issue 1; Other Information: DOI: 10.1016/j.taap.2007.02.015; PII: S0041-008X(07)00103-2; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BIOLOGICAL ADAPTATION
BIOLOGICAL STRESS
COMMUNICATIONS
DOSE-RESPONSE RELATIONSHIPS
RECOMMENDATIONS
SPECTRA
STIMULI