The Risk of Early and Late Lung Sequelae After Conformal Radiotherapy in Breast Cancer Patients

Journal Article · Sun Jul 01 04:00:00 EDT 2007 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2006.12.016· OSTI ID:20951692

Kahan, Zsuzsanna ^[1]; Csenki, Melinda ^[1]; Varga, Zoltan ^[1]; Szil, Elemer ^[1]; Cserhati, Adrienn ^[1]; Balogh, Attila ^[2]; Gyulai, Zsofia ^[2]; Mandi, Yvette ^[2]; Boda, Krisztina ^[3]; Thurzo, Laszlo ^[1]

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1. Department of Oncotherapy, University of Szeged, Szeged (Hungary)
2. Department of Microbiology and Immunobiology, University of Szeged, Szeged (Hungary)
3. Department of Medical Informatics, University of Szeged, Szeged (Hungary)

Purpose: To study the risks of early and late radiogenic lung damage in breast cancer patients after conformal radiotherapy. Methods and Materials: Radiogenic lung sequelae were assessed prospectively in 119 patients by means of clinical signs, radiologic abnormalities, and the mean density change (MDC) of the irradiated lung on CT. Results: Significant positive associations were detected between the development of lung abnormalities 3 months or 1 year after the radiotherapy and the age of the patient, the ipsilateral mean lung dose (MLD), the radiation dose to 25% of the ipsilateral lung (D{sub 25%}) and the volume of the ipsilateral lung receiving 20 Gy (V{sub 20Gy}). The irradiation of the axillary and supraclavicular lymph nodes favored the development of pneumonitis but not that of fibrosis. No relation was found between the preradiotherapy plasma TGF-{beta} level and the presence of radiogenic lung damage. At both time points, MDC was strongly related to age. Significant positive associations were demonstrated between the risks of pneumonitis or fibrosis and the age of the patient, MLD, D{sub 25%}, and V{sub 20Gy}. A synergistic effect of MLD, D{sub 25%}, and V{sub 20Gy} with age in patients older than 59 years is suggested. Conclusion: Our analyses indicate that the risks of early and late radiogenic lung sequelae are strongly related to the age of the patient, the volume of the irradiated lung, and the dose to it.

• OSTI ID: 20951692
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 68; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
FIBROSIS
HEALTH HAZARDS
IRRADIATION
LUNGS
LYMPH NODES
MAMMARY GLANDS
PATIENTS
PNEUMONITIS
RADIATION DOSES
RADIOTHERAPY