A Prospective Evaluation of Helical Tomotherapy

Journal Article · Fri Jun 01 00:00:00 EDT 2007 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2006.11.052· OSTI ID:20951686

Bauman, Glenn ^[1]; Yartsev, Slav ^[1]; Rodrigues, George ^[1]; Lewis, Craig; Hammond, Alex; Perera, Francisco; Venkatesan, Varagur M ^[1]; Yu, Edward; Lock, Michael; Battista, Jerry; Van Dyk, Jake ^[1]; Baily, Laura; Coad, Terry C; Trenka, Kris C; Warr, Barbara ^[1]; Kron, Tomas ^[2]

---

1. London Regional Cancer Program, London, Ontario (Canada)
2. Peter MacCallum Cancer Centre, Melbourne (Australia)

Purpose: To report results from two clinical trials evaluating helical tomotherapy (HT). Methods and Materials: Patients were enrolled in one of two prospective trials of HT (one for palliative and one for radical treatment). Both an HT plan and a companion three-dimensional conformal radiotherapy (3D-CRT) plan were generated. Pretreatment megavoltage computed tomography was used for daily image guidance. Results: From September 2004 to January 2006, a total of 61 sites in 60 patients were treated. In all but one case, a clinically acceptable tomotherapy plan for treatment was generated. Helical tomotherapy plans were subjectively equivalent or superior to 3D-CRT in 95% of plans. Helical tomotherapy was deemed equivalent or superior in two thirds of dose-volume point comparisons. In cases of inferiority, differences were either clinically insignificant and/or reflected deliberate tradeoffs to optimize the HT plan. Overall imaging and treatment time (median) was 27 min (range, 16-91 min). According to a patient questionnaire, 78% of patients were satisfied to very satisfied with the treatment process. Conclusions: Helical tomotherapy demonstrated clear advantages over conventional 3D-CRT in this diverse patient group. The prospective trials were helpful in deploying this technology in a busy clinical setting.

• OSTI ID: 20951686
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 68, Issue 2; Other Information: DOI: 10.1016/j.ijrobp.2006.11.052; PII: S0360-3016(06)03633-9; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CLINICAL TRIALS
COMPUTERIZED TOMOGRAPHY
IMAGES
PATIENTS
RADIATION DOSES
RADIOTHERAPY
TECHNOLOGY ASSESSMENT