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Title: Evaluation of the accuracy of fetal dose estimates using TG-36 data

Abstract

The American Association of Physicists in Medicine Radiation Therapy Committee Task Group 36 report (TG-36) provides guidelines for managing radiation therapy of pregnant patients. Included in the report are data that can be used to estimate the dose to the fetus. The purpose of this study is to evaluate the accuracy of these fetal dose estimates as compared to clinically measured values. TG-36 calculations were performed and compared with measurements of the fetal dose made in vivo or in appropriately-designed phantoms. Calculation and measurement data was collected for eight pregnant patients who underwent radiation therapy at the MD Anderson Cancer Center as well as for several fetal dose studies in the literature. The maximum measured unshielded fetal dose was 47 cGy, which was 1.5% of the prescription dose. For all cases, TG-36 calculations and measured fetal doses differed by up to a factor of 3--the ratio of the calculated to measured dose ranged from 0.34 to 2.93. On average, TG-36 calculations underestimated the measured dose by 31%. No significant trends in the relationship between the calculated and measured fetal doses were found based on the distance from, or the size of, the treatment field.

Authors:
; ; ;  [1];  [2];  [2]
  1. Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 (United States)
  2. (United States)
Publication Date:
OSTI Identifier:
20951140
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 34; Journal Issue: 4; Other Information: DOI: 10.1118/1.2710332; (c) 2007 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; DOSIMETRY; DRUGS; EVALUATION; FETUSES; GYNECOLOGY; IN VIVO; NEOPLASMS; PATIENTS; PHANTOMS; RADIATION DOSES; RADIATION PROTECTION; RADIOTHERAPY; RECOMMENDATIONS

Citation Formats

Kry, Stephen F., Starkschall, George, Antolak, John A., Salehpour, Mohammad, Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, and Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030. Evaluation of the accuracy of fetal dose estimates using TG-36 data. United States: N. p., 2007. Web. doi:10.1118/1.2710332.
Kry, Stephen F., Starkschall, George, Antolak, John A., Salehpour, Mohammad, Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, & Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030. Evaluation of the accuracy of fetal dose estimates using TG-36 data. United States. doi:10.1118/1.2710332.
Kry, Stephen F., Starkschall, George, Antolak, John A., Salehpour, Mohammad, Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, and Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030. Sun . "Evaluation of the accuracy of fetal dose estimates using TG-36 data". United States. doi:10.1118/1.2710332.
@article{osti_20951140,
title = {Evaluation of the accuracy of fetal dose estimates using TG-36 data},
author = {Kry, Stephen F. and Starkschall, George and Antolak, John A. and Salehpour, Mohammad and Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905 and Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030},
abstractNote = {The American Association of Physicists in Medicine Radiation Therapy Committee Task Group 36 report (TG-36) provides guidelines for managing radiation therapy of pregnant patients. Included in the report are data that can be used to estimate the dose to the fetus. The purpose of this study is to evaluate the accuracy of these fetal dose estimates as compared to clinically measured values. TG-36 calculations were performed and compared with measurements of the fetal dose made in vivo or in appropriately-designed phantoms. Calculation and measurement data was collected for eight pregnant patients who underwent radiation therapy at the MD Anderson Cancer Center as well as for several fetal dose studies in the literature. The maximum measured unshielded fetal dose was 47 cGy, which was 1.5% of the prescription dose. For all cases, TG-36 calculations and measured fetal doses differed by up to a factor of 3--the ratio of the calculated to measured dose ranged from 0.34 to 2.93. On average, TG-36 calculations underestimated the measured dose by 31%. No significant trends in the relationship between the calculated and measured fetal doses were found based on the distance from, or the size of, the treatment field.},
doi = {10.1118/1.2710332},
journal = {Medical Physics},
number = 4,
volume = 34,
place = {United States},
year = {Sun Apr 15 00:00:00 EDT 2007},
month = {Sun Apr 15 00:00:00 EDT 2007}
}