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Title: Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma

Abstract

Purpose: To clarify the radiotherapy clinical target volume (CTV) margin needed for esophageal squamous-cell carcinoma (SCC) and gastroesophageal junction (GEJ) adenocarcinoma. Methods and Materials: Surgical specimens of esophageal SCC (n = 34) and GEJ adenocarcinoma (n = 32) were prospectively collected and analyzed for microscopic spread along the esophagus and GEJ both proximally and distally from gross tumor and for lymph node (LN) metastasis. Results: For SCC, the mean microscopic spread beyond the gross tumor was 10.5 {+-} 13.5 mm proximally (<30 mm in 32 of 34 cases) and 10.6 {+-} 8.1 mm distally (<30 mm in 33 of 34 cases). For GEJ adenocarcinoma, the spread was 10.3 {+-} 7.2 mm proximally (<30 mm in 29 of 29 cases) and 18.3 {+-} 16.3 mm distally (<30 mm in 27 of 32 cases). The extent of microscopic spread of cancer was significantly associated with pathologic T stage (p = 0.012). LN metastases were observed in 12 (35%) of 34 patients with middle and lower esophageal SCC and 15 (47%) of 32 patients with GEJ adenocarcinoma. Conclusions: The extent of microscopic spread within esophagus (recommended CTV margin) was <30 mm in about 94% of cases of esophageal cancer, except for distal microscopicmore » spread in GEJ adenocarcinoma, in which 50 mm was needed to cover about 94% of cases.« less

Authors:
 [1];  [2];  [3];  [3];  [3];  [4];  [5];  [5];  [5];  [6];  [7];  [8]
  1. Department of Radiation Oncology, Beijing University First Hospital, Beijing (China)
  2. (China)
  3. Department of Radiation Oncology, Hebei Medical University Fourth Hospital, Shijiazhuang (China)
  4. Department of Thoracic Surgery, Hebei Medical University Fourth Hospital, Shijiazhuang (China)
  5. Department of Pathology, Hebei Medical University Fourth Hospital, Shijiazhuang (China)
  6. Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)
  7. Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)
  8. Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States). E-mail: jychang@mdanderson.org
Publication Date:
OSTI Identifier:
20944678
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2006.09.015; PII: S0360-3016(06)02986-5; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; ESOPHAGUS; LYMPH NODES; METASTASES; PATIENTS; RADIOTHERAPY; SURGERY

Citation Formats

Gao Xianshu, Department of Radiation Oncology, Hebei Medical University Fourth Hospital, Shijiazhuang, Qiao Xueying, Wu Fengpeng, Cao Li, Meng Xianli, Dong Zhiming, Wang Xiaoling, Gao Guodong, Wu, T.-T., Komaki, Ritsuko, and Chang, Joe Y. Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma. United States: N. p., 2007. Web.
Gao Xianshu, Department of Radiation Oncology, Hebei Medical University Fourth Hospital, Shijiazhuang, Qiao Xueying, Wu Fengpeng, Cao Li, Meng Xianli, Dong Zhiming, Wang Xiaoling, Gao Guodong, Wu, T.-T., Komaki, Ritsuko, & Chang, Joe Y. Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma. United States.
Gao Xianshu, Department of Radiation Oncology, Hebei Medical University Fourth Hospital, Shijiazhuang, Qiao Xueying, Wu Fengpeng, Cao Li, Meng Xianli, Dong Zhiming, Wang Xiaoling, Gao Guodong, Wu, T.-T., Komaki, Ritsuko, and Chang, Joe Y. Thu . "Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma". United States. doi:.
@article{osti_20944678,
title = {Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma},
author = {Gao Xianshu and Department of Radiation Oncology, Hebei Medical University Fourth Hospital, Shijiazhuang and Qiao Xueying and Wu Fengpeng and Cao Li and Meng Xianli and Dong Zhiming and Wang Xiaoling and Gao Guodong and Wu, T.-T. and Komaki, Ritsuko and Chang, Joe Y.},
abstractNote = {Purpose: To clarify the radiotherapy clinical target volume (CTV) margin needed for esophageal squamous-cell carcinoma (SCC) and gastroesophageal junction (GEJ) adenocarcinoma. Methods and Materials: Surgical specimens of esophageal SCC (n = 34) and GEJ adenocarcinoma (n = 32) were prospectively collected and analyzed for microscopic spread along the esophagus and GEJ both proximally and distally from gross tumor and for lymph node (LN) metastasis. Results: For SCC, the mean microscopic spread beyond the gross tumor was 10.5 {+-} 13.5 mm proximally (<30 mm in 32 of 34 cases) and 10.6 {+-} 8.1 mm distally (<30 mm in 33 of 34 cases). For GEJ adenocarcinoma, the spread was 10.3 {+-} 7.2 mm proximally (<30 mm in 29 of 29 cases) and 18.3 {+-} 16.3 mm distally (<30 mm in 27 of 32 cases). The extent of microscopic spread of cancer was significantly associated with pathologic T stage (p = 0.012). LN metastases were observed in 12 (35%) of 34 patients with middle and lower esophageal SCC and 15 (47%) of 32 patients with GEJ adenocarcinoma. Conclusions: The extent of microscopic spread within esophagus (recommended CTV margin) was <30 mm in about 94% of cases of esophageal cancer, except for distal microscopic spread in GEJ adenocarcinoma, in which 50 mm was needed to cover about 94% of cases.},
doi = {},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 2,
volume = 67,
place = {United States},
year = {Thu Feb 01 00:00:00 EST 2007},
month = {Thu Feb 01 00:00:00 EST 2007}
}