The effect of angiotensin 1-7 on tyrosine kinases activity in rat anterior pituitary
- Department of Molecular Neurochemistry, Medical University of Lodz (Poland)
- Department of Student, Medical University of Lodz (Poland)
- Department of Comparative Endocrinology, Medical University of Lodz (Poland)
Angiotensin 1-7 (Ang 1-7) is a peptide originated from Ang II. It is known that in vessels Ang 1-7 shows opposite effects to Ang II. Ang 1-7 can modify processes of proliferation. However, Ang 1-7 action in pituitary gland cells was never studied. Moreover, the specific binding sites for Ang 1-7 are still unknown. The aim of this study was to examine the effects of Ang 1-7 on tyrosine kinases (PTKs) activity in the anterior pituitary. The reaction of phosphorylation was carrying out in presence of different concentration of Ang 1-7 and losartan (antagonist of AT1 receptor) and PD123319 (antagonist of AT2). Our results show that Ang 1-7 inhibited activity of PTK to 60% of basic activity. Losartan did not change the Ang 1-7-induced changes in PTKs activity. The presence of PD123319 together with Ang 1-7 caused stronger inhibition PTKs activity than Ang 1-7 alone. These observations suggest that Ang 1-7 binds to the novel, unknown, specific for this peptide receptor.
- OSTI ID:
- 20854431
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 347, Issue 3; Other Information: DOI: 10.1016/j.bbrc.2006.06.109; PII: S0006-291X(06)01404-5; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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