Liver PPAR{alpha} and UCP2 are involved in the regulation of obesity and lipid metabolism by swim training in genetically obese db/db mice
- Department of Physical Education, Sookmyung Women's University, Seoul 140-742 (Korea, Republic of)
- Department of Life Sciences, Mokwon University, Taejon 302-729 (Korea, Republic of)
- Department of Formula-ology, College of Oriental Medicine and Korea Institute of Oriental Medicine, Dongeui University, Busan 614-052 (Korea, Republic of)
Swim training for 6 weeks significantly decreased body weight gain, adipose tissue mass, and adipocyte size in both sexes of genetically obese db/db mice compared with their respective sedentary controls. Swim training also caused significant decreases in serum levels of free fatty acids, triglycerides, and total cholesterol in both sexes of obese mice. Concomitantly, hepatic mRNA levels of peroxisome proliferator-activated receptor {alpha} (PPAR{alpha}) target enzymes responsible for mitochondrial and peroxisomal fatty acid {beta}-oxidation were significantly increased by swim training. Moreover, mRNA levels of uncoupling protein 2 (UCP2) in liver were also markedly increased by swim training. In conclusion, these results suggest that swim training-induced transcriptional activation of hepatic PPAR{alpha} target enzymes and UCP2 may effectively prevent body weight gain, adiposity, and lipid disorders caused by leptin receptor deficiency in both sexes of mice.
- OSTI ID:
- 20854345
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 345, Issue 3; Other Information: DOI: 10.1016/j.bbrc.2006.04.182; PII: S0006-291X(06)01023-0; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Voluntary exercise prevents colonic inflammation in high-fat diet-induced obese mice by up-regulating PPAR-γ activity
Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: Activation of PPAR-{alpha}